Lancet Oncol 2022; 23: e251–312Published OnlineMay 9, 2022 https://doi.org/10.1016/S1470-2045(21)00720-8
In sub-Saharan Africa (SSA), urgent action is needed to curb a growing crisis in cancer incidence and mortality.
Without rapid interventions, data estimates show a major increase in cancer mo...rtality from 520 348 in 2020 to about
1 million deaths per year by 2030. Here, we detail the state of cancer in SSA, recommend key actions on the basis of
analysis, and highlight case studies and successful models that can be emulated, adapted, or improved across the
region to reduce the growing cancer crises. Recommended actions begin with the need to develop or update national
cancer control plans in each country. Plans must include childhood cancer plans, managing comorbidities such as
HIV and malnutrition, a reliable and predictable supply of medication, and the provision of psychosocial, supportive,
and palliative care. Plans should also engage traditional, complementary, and alternative medical practices employed
by more than 80% of SSA populations and pathways to reduce missed diagnoses and late referrals. More substantial
investment is needed in developing cancer registries and cancer diagnostics for core cancer tests.
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Le document fournit des directives complètes pour la gestion des flambées de choléra, y compris la détection, la confirmation, la réponse, le traitement et la prévention. Il met l'accent sur l'importance de la réhydratation, de l'assainissement de l'eau, de la promotion de l'hygiène et de la... mobilisation communautaire pour limiter la propagation. Ce guide est conçu pour les professionnels de la santé et les autorités publiques afin d'assurer une réponse efficace et coordonnée.
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Élargir l’accès aux soins pour
lutter contre les troubles mentaux,
neurologiques et liés à l’utilisation
de substances psychoactives
Regulation of the Minister of Health of the Republic of Indonesia on Impact Reduction for Injecting Narcotics Drug Users
NAPZA : Narkotika, Psikotropika dan Zat Adiktif Lainnya (Narcotics, Psychotropic and Other Addictive Substances)
In preparing this paper, the Pharmacovigilance Group of the Pan American Health Organization’s Pan American Network for Drug Regulatory Harmonization (PANDRH) adopted the perspective of PAHO/WHO, which considers Pharmacovigilance, an essential component of public health programs. Its intention was... to facilitate the development of pharmacovigilance systems in the Region of the Americas and improve, strengthen, and promote the adoption of good practices to improve safety for patients and the general population, based on the needs of the Region.
Document also available in Spanish and Portuguese!
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Ce guide sera particulièrement utile pour les gestionnaires de programme qui concoivent, gèrent et évaluent les systèmes logistique pour les programmes de santé. En outre, décideurs, intervenants du système et toute personne travaillant dans la logistique trouveront dans ce guide une utile a...pproche globale du système. Les concepts et termes clés sont clairement définis et expliqués; le document comprend des informations détaillées sur la conception et la mise en œuvre de systèmes d’information, de la gestion logistique et des systèmes de contrôle d’inventaire. Aperçus de quantification; processus d’approvisionnement; stockage, transport et sélection des produits sont aussi inclus dans le document.
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BMC Infectious Diseases 2012, 12:352/1471-2334/12/352
Orientations provisoires, 27 mai 2021
The cardiovascular disease continuum begins with risk factors such as diabetes mellitus (DM), progresses to vasculopathy and myocardial dysfunction, and finally ends with cardiovascular death. Diabetes is associated with a 2- to 4-fold increased risk for heart failure (HF). Moreover, HF patients wit...h DM have a worse prognosis than those without DM. Diabetes can cause myocardial ischemia via micro- and macrovasculopathy and can directly exert deleterious effects on the myocardium. Hyperglycemia, hyperinsulinemia, and insulin resistance can cause alterations in vascular homeostasis. Then, reduced nitric oxide and increased reactive oxygen species levels favor inflammation leading to atherothrombotic progression and myocardial dysfunction. The classification, diagnosis, and treatment of HF for a patient with and without DM remain the same. Until now, drugs targeting neurohumoral and metabolic pathways improved mortality and morbidity in HF with reduced ejection fraction (HFrEF). Therefore, all HFrEF patients should receive guideline-directed medical therapy. By contrast, drugs modulating neurohumoral activity did not improve survival in HF with preserved ejection fraction (HFpEF) patients. Trials investigating whether sodium-glucose cotransporter-2 inhibitors are effective in HFpEF are on-going. This review will summarize the epidemiology, pathophysiology, and treatment of HF in diabetes.
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This Framework offers a coherent approach for eliminating tuberculosis (TB) in low-incidence countries. It is designed to guide national policy-makers and those responsible for technical aspects of the national TB response in accelerating efforts towards elimination. The document will also be inform...ative for public health surveillance officers, practitioners and nongovernmental and civil society partners working on natioal TB care and prevention and serving the populations most vulnerable to TB.
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Volume 1 covers emergency triage assessment and treatment, and acute care for a severely ill or acutely injured patient for approximately the first 24 hours of care. It describes the clinical procedures commonly used in emergency and acute care, and gives a summary of the medicines used and the step...s necessary for infection control.
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