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Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are
...
limited to antibiotics with severe side effects. Here, we show that M. ulcerans is susceptible to the anti-tubercular drug Q203 and related compounds targeting the respiratory cytochrome bc1:aa3. While the cytochrome bc1:aa3 is the primary terminal oxidase in Mycobacterium tuberculosis, the presence of an alternate bd-type terminal oxidase limits the bactericidal and sterilizing potency of Q203 against this bacterium. M. ulcerans strains found in Buruli ulcer patients from Africa and Australia lost all alternate terminal electron acceptors and rely exclusively on the cytochrome bc1:aa3 to respire. As a result, Q203 is bactericidal at low dose against M. ulcerans replicating in vitro and in mice, making the drug a promising candidate for Buruli ulcer treatment.
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The report provides an overview of the disaster risk reduction and management in Nepal, a country under threat of multiple natural hazards: earthquakes, floods, landslides, fires, storms, the epidemics, and others. It presents background information on the country, its disaster profile, its legal an
...
d institutional framework, the country's achievements in regards to the Hyogo Framework for Action, and looks at the challenges and future steps in the area of disaster management in Nepal.
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Philippines: HIV Immunization Guidelines
Rontgene M. Solante, Manolito L. Chua
Philippine Society for Microbiology and Infectious Diseases
(2010)
C1
This paper brings together lessons from interviews with humanitarians and local responders, as well as existing literature, about the use of quarantine in urban environments during the humanitarian response to the Ebola Crisis
This report from Human Rights Watch found that South Africa has failed to guarantee the right to education for many of the country’s children and young adults due to widespread discrimination against children with disabilities in enrollment decisions. Human Rights Watch research in five out of Sou
...
th Africa’s nine provinces showed that children with disabilities face discriminatory physical and attitudinal barriers, often beginning early in children’s lives when government officials classify them according to their disabilities. Human Rights Watch August 2015
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Statement
Impact of migration on infectious diseases in Europe | August 2007 | 1-7
Establishing a community-based disease surveillance system is key step to improving the early detection and assessment of outbreaks
An attempt has been made to map the incidence of uni-dimensional and multi-dimensional poverty simultaneously arguably for the first time in Pakistan. While multi-dimensional poverty map is calculated using PSLM 2010-11; small area estimation technique is utilized to map uni-dimensional poverty usin
...
g both nationally representative HIES (Household Integrated Economic Survey) and district-level representative PSLM (Pakistan Standard of Living Measurement) for the same year of 2010-11. The result indicates the existence of spatial distribution of poverty pockets in each of the four provinces of Pakistan. Furthermore, it is also observed that these pockets of poverty are more concentrated in the desert and mountains regions of the country.
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Rapport mondial sur la prévention des traumatismes chez l’enfant
Organisation mondiale de la Santé (OMS), Fonds des Nations Unies pour l’enfance (UNICEF)
Peden, Margie et al.
(2008)
C_WHO
Plus de 2000 enfants meurent chaque jour des suites de traumatismes involontaires ou accidentels. Chaque année des dizaines de milliers d'autres sont hospitalisés pour des blessures qui les laissent souvent handicapés à vie.
Ce rapport conjoint de l'OMS et de l'UNICEF établit le premier b ... ilan mondial des principales causes à l'origine des traumatismes involontaires touchant des enfants: les accidents de la route, les noyades, les brûlures, les chutes et les empoisonnements. more
Ce rapport conjoint de l'OMS et de l'UNICEF établit le premier b ... ilan mondial des principales causes à l'origine des traumatismes involontaires touchant des enfants: les accidents de la route, les noyades, les brûlures, les chutes et les empoisonnements. more
Prepared as an outcome of ICMR Subcommittee on Cancer Cervix | This consensus document on management of cervix cancer summarizes the modalities of treatment including the site-specific anti-cancer therapies, supportive and palliative care and molecular markers and research questions. It also interwe
...
aves clinical, biochemical and epidemiological studies.
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Prepared as an outcome of ICMR Subcommittee on Soft Tissue Sarcoma and Osteosarcoma | This consensus document on Management of Soft Tissue Sarcoma and Osteosarcoma summarizes the modalities of treatment including the site-specific anti-cancer therapies, supportive and palliative care and molecular
...
markers and research questions. It also interweaves clinical, biochemical and epidemiological studies.
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