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Investment Case - Eighth Replenishment 2025 - Executive Summary

The Global Fund (2025) CC

To deliver on the Global Fund Strategy milestones for 2028 and ensure we keep the SDG 3 target within reach, we need to raise US$18 billion to fund the Global Fund’s next three-year grant cycle.

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Argumentos a Favor de la Inversión - Octava Reposición de Recursos 2025 - Resumen ejecutivo

El Fondo Mundial (2025) CC

Si queremos cumplir los hitos de la Estrategia del Fondo Mundial para 2028 y mantener a nuestro alcance la meta del ODS 3, necesitamos recaudar 18.000 millones USD para financiar el próximo ciclo de subvenciones trienal del Fondo Mundial.

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Shifting official development assistance during COVID-19: earmarking, donor concentration and loans

Woskie L., Wenham C. BMJ Global Health (2024) CC

In contrast to bilateral aid, aid disbursed from multilateral institutions increased significantly at the onset of the COVID-19 pandemic. Yet, at a time when a coherent and effective multilateral response is needed most, the COVID-19 pandemic revealed a shifting landscape of donor agencies that... more

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The Cost-Effectiveness of Health Aid

Fan V.Y., Webster B.S., Subramanian V., et al. Center for Global Development (2024) CC

One approach to development assistance for health, or health aid, emphasizes the ex ante selection of cost-effective health interventions, an approach that began with the World Development Report (1993) on Investing in Health and has since been adopted by the Effective Altruism community. But just h... more

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Africa’s Health Financing in a New Era

Africa Centres for Disease Control and Prevention (Africa CDC) (2025) CC

Africa’s health sector is facing an unprecedented financing crisis, driven by a sharp decline of 70% in Official Development Assistance (ODA) from 2021 to 2025 and deep-rooted structural vulnerabilities. This collapse is placing immense pressure on Africa’s already fragile health systems as ODA ...is seen as the backbone of critical health programs: pandemic preparedness, maternal and child health services, disease control programs are all at risk, threatening Sustainable Development Goal 3 and Universal Health Coverage. Compounding this is Africa’s spiraling debt, with countries expected to service USD 81 billion by 2025—surpassing anticipated external financing inflows—further eroding fiscal space for health investments. Level of domestic resources is low. TThe Abuja Declaration of 2001, a pivotal commitment made by African Union (AU) member states, aimed to reverse this trend by pledging to allocate at least 15% of national budgets to the health sector. However, more than two decades later, only three countries—Rwanda, Botswana, and Cabo Verde—have consistently met or exceeded this target (WHO, 2023). In contrast, over 30 AU member states remain well below the 10% benchmark, with some allocating as little as 5–7% of their national budgets to health. In addition, only 16 (29%) of African countries currently have updated versions of National Health Development Plan (NHDP) supported by a National Health Financing Plan (NHFP). These two documents play a critical role in driving internal resource mobilisation. At the same time, public health emergencies are surging, rising 41%—from 152 in 2022 to 213 in 2024—exposing severe under-resourcing of health infrastructure and workforce. Recurring outbreaks (Mpox, Ebola, cholera, measles, Marburg…) alongside effects of climate change and humanitarian crises in Eastern DRC, the Sahel, and Sudan, are overwhelming systems stretched by chronic underfunding. The situation is worsened by Africa’s heavy dependency with over 90% of vaccines, medicines, and diagnostics being externally sourced—leaving countries vulnerable to global supply chain shocks. Health worker shortages persist, with only 2.3 professionals per 1,000 people (below the WHO’s recommended 4.45), and fewer than 30% of systems are digitized, undermining disease surveillance and early warning. Without decisive action, Africa CDC projects the continent could reverse two decades of health progress, face 2 to 4 million additional preventable deaths annually, and a heightened risk of a pandemic emerging from within. Furthermore, 39 million more Africans could be pushed into poverty by 2030 due to intertwined health and economic shocks. This is not just a sectoral crisis—it is an existential threat to Africa’s political, social, and economic resilience, and global stability. In response, African leaders, under Africa CDC’s stewardship, are advancing a comprehensive three-pillar strategy centered on domestic resource mobilization, innovative financing, and blended finance. more

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PEPFAR: Exploring Co-Financing as a Tool for Domestic Resource Mobilization

Kates J. Kaiser Family Foundation (KFF) (2024) CC

There is growing pressure on PEPFAR, the U.S. global HIV program, to increase its planning for sustainability, including through domestic resource mobilization and, ultimately, transitioning financing at least in part to recipient countries. While this is connected to a broader push in global healt... more

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Factors associated with the unsuccessful TB treatment outcomes in the northern regions of Namibia: a mixed methods study

Amkongo, M.; Mitonga, H. K.; Alfeus, A.; et al. (2023) CC2

BMC Infectious Diseases volume 23, Article number: 342 (2023). Tuberculosis (TB) is among the leading causes of death globally. The disease has a huge burden in Namibia, with a case notification rate of at least 442 per 100,000. To date, Namibia is among the countries with the highest global TB bur... more

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Malaria Case Management Training Manual for Health Professionals in Ethiopa. Participant Manual

Federal Ministry of Health FMOH, EThiopia (2022) CC

This malaria case management training manual was developed by the Federal Ministry of Health (FMOH) of Ethiopia, in collaboration with several national and international partners. Primarily based on WHO guidelines and training materials, as well as the 2022 national malaria guidelines and various te... more

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Clinical profile of malaria and HIV co-infection

Tudu K.M., M.K. Bariha, M.K. Mohapatra, et al (2020) C2

International Journal of Advances in Medicine. Vol. 7 No. 7 (2020): July 2020 . This study explores the clinical characteristics and outcomes of patients with concurrent malaria and HIV infection, a combination that is relatively understudied in India.

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Surveillance template protocol for pfhrp2/pfhrp3 gene deletions

World Health Organization WHO (2024) C_WHO

2nd edition. The purpose of this document is to present updated standardized protocols that P. falciparum-endemic countries can use to determine the prevalence of parasites with pfhrp2/3 gene deletions causing negative HRP2 RDT results among symptomatic falciparum patients. The findings should be us... more

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Current Developments in Malaria Vaccination: A Concise Review on Implementation, Challenges, and Future Directions

Sallam, M.; A.O.Al-Kathib, K.S.Al-Mazhoum, et al. Dove Press (2025) CC

Clinical Pharmacology: Advances and Applications, 2025:17 29–47

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Malaria vaccines: the 60‑year journey of hope and final success—lessons learned and future prospects

El‑Moamly, A.A.; and M. A. El‑Sweify (2023) CC

Tropical Medicine and Health (2023) 51:29

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Climate-proofing a malaria eradication strategy

Nissan, H.; I. Ukawuba, and M. Thomson BMC (2021) CC

Malaria Journal (2021) 20:190

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Diabetes footcare in dark skin tones

Diabetes Africa (2024) CC

This handbook is designed to provide essential information as well as quick tips to improve foot care for people with dark skin tone living with diabetes.

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WHO global anaemia estimates: key findings, 2025

World Health Organization WHO (2025) C_WHO

The brief on key findings from the 2025 edition of the WHO anaemia estimates provides a snapshot of the current status of anaemia among women aged 15–49 years at the country, regional, and global levels, along with progress toward achieving the global anaemia target by 2030, in alignment with the ... more

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Zoonotic Disease: Prevention and Control Strategy 2025-2029
recommended

Africa Center for Disease Control and Prevention CDC (2025) CC

Public health challenges over the past decade have highlighted the importance of approaching health through a holistic lens of human, animal, and environmental sectors, recognizing the need for a collaborative response against shared threats. Zoonotic diseases, transmitted between humans and animals... more

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Best Buys to Accelerate Disease Elimination in the Americas

Pan American Health Organization PAHO (2025) C_WHO

The Best Buys for Disease Elimination is a practical, evidence-based guide to the most effective actions for countries to implement in order to eliminate communicable diseases. The guide highlights the efficient use of resources and prioritizing populations in vulnerable situations. “The Region... more

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Strategic Plan of the Pan American Health Organization 2026–2031

Pan American Health Organization PAHO (2025) CC

This plan, approved by the Organization’s 62nd Directing Council, was shaped by extensive consultations with countries and stakeholders, and commits to transformative health outcomes over the next six years, tackling noncommunicable diseases (NCDs), mental health, health security, fragmented healt... more

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National outbreak response handbook

World Health Organization WHO; Global Outbreak Alert and Response Network GOARN (2024) C_WHO

Strengthening global health security to protect the world against future epidemics and pandemics requires well-tested and decentralized capacities for the local detection and rapid containment of outbreaks of infectious disease. For such capacities to translate into effective response actions, ind... more

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Early Warning Alert And Response Network in emergencies: evaluation protocol

World Health Organisation (WHO) Centers for Disease Control and Prevention (CDC) (2018) C_WHO

The document provides a standardized protocol for evaluating the Early Warning Alert and Response Network (EWARN), a surveillance system used during humanitarian emergencies when regular national health surveillance may be disrupted. The purpose of EWARN is to detect outbreaks of communicable diseas... more

Zoonotic Disease: Prevention and Control Strategy 2025-2029 recommended

Zoonotic Disease: Prevention and Control Strategy 2025-2029
recommended