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Buruli ulcer is a chronic, progressive skin disease caused by infection with Mycobacterium ulcerans. It is currently considered to be one of the neglected tropical diseases; less common than tuberculosis but more common than leprosy. The initial les
...
ion is a painless subcutaneous nodule, usually less than 5 cm diameter and adherent to skin. The nodule typically breaks down centrally after days to weeks forming an ulcer with undermined edges. Thus, the external appearance of the ulcer underestimates the true size of the affected area. The patient remains well and there is no pain unless secondary bacterial infection occurs. Other forms of M. ulcerans disease include a firm plaque lesions that behaves in the same way as the nodule or an oedematous lesion that is more aggressive and extends rapidly resulting in a very large ulcer.
Any age group can be affected by Buruli ulcer diseases, but the incidence peaks at 5 to 15 years. Ulcers are most frequently on the limbs but can be on the trunk or head, sometimes with catastrophic consequences such as loss of sight or loss of breast or genital tissue. Healing close to a joint can result in contracture, and sometimes there is so much tissue destruction on a limb that amputation is unavoidable. Occasionally osteomyelitis occurs in bone adjacent to a skin lesion but involvement of other organs is rare. Disseminated disease with HIV has been reported.
more
Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are
...
limited to antibiotics with severe side effects. Here, we show that M. ulcerans is susceptible to the anti-tubercular drug Q203 and related compounds targeting the respiratory cytochrome bc1:aa3. While the cytochrome bc1:aa3 is the primary terminal oxidase in Mycobacterium tuberculosis, the presence of an alternate bd-type terminal oxidase limits the bactericidal and sterilizing potency of Q203 against this bacterium. M. ulcerans strains found in Buruli ulcer patients from Africa and Australia lost all alternate terminal electron acceptors and rely exclusively on the cytochrome bc1:aa3 to respire. As a result, Q203 is bactericidal at low dose against M. ulcerans replicating in vitro and in mice, making the drug a promising candidate for Buruli ulcer treatment.
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Pan African Medical Journal. 2025;51:65.
South Eastern European Journal of Public Health, EEJPH 2016, posted: 11 January 2016. DOI 10.4119/UNIBI/SEEJPH-2016-85
Plan estratégico nacional multisectorial para el control de la tuberculosis en El Salvador 2017-2021
Menjívar Escalante, E.V.; E.A. Espinoza Fiallos, J.O. Robles Ticas
Ministerio de Salud El Salvador
(2018)
CC
National multi-sectoral strategic plan for tuberculosis control in El Salvador 2017-2021
Antimicrobial Resistance and Infection Control 2014,3 :31
Tuberculose -M anuel pour les etudiants en medecine
recommended
N. Ait-Khaled, D. Enarson
Organisation mondiale de la Santé; Union Internationale Contra la Tuberculose et les Maladies Respiratoires
(1999)
C_WHO
WHO/CDS/TB/99.272
Distr.: General, Original: French
Iniciativa Global de Laboratorio – Entrenamiento en Xpert MTB/RIF
Accessed December 2017
Por favor descargue los 12 módulos todos
INT J TUBERC LUNG DIS 22(2):197–205 http://dx.doi.org/10.5588/ijtld.17.0245
Pathogens 2022, 11, 33. https://doi.org/10.3390/pathogens11010033
The 7th edition of the Orange Guide provides practical guidance to health workers on the front line of TB control. It includes sections on HIV, MDR-TB and a review of the recommended treatment regimens
Guidelines for the Prevention of Tuberculosis in Health Care Facilities in Resource-limited Settings
These guidelines are designed for settings with limited resources to provide inexpensive and effective control strategies for prevention of TB transmission in health care workers (HCW).
Management of Diabetes Mellitus-Tuberculosis
recommended
1st edition
This resource provides practical guidance for front line health workers responsible for the diagnosis, management and care of patients with these two diseases. Published in collaboration with the World Diabetes Foundation
Tuberculosis Infection Control Guidelines
recommended
Second Edition