Clinical Microbiology and Infection Volume 21, Issue 5, May 2015, Pages 433-443;
The neglected zoonotic diseases (NZDs) have been all but eradicated in wealthier countries, but remain major causes of ill-health and mortality across Africa, Asia, and Latin America. This neglect is, in part, a conse...quence of under-reporting, resulting in an underestimation of their global burden that downgrades their relevance to policy-makers and funding agencies. Increasing awareness about the causes of NZDs and how they can be prevented could reduce the incidence of many endemic zoonoses.
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Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are... limited to antibiotics with severe side effects. Here, we show that M. ulcerans is susceptible to the anti-tubercular drug Q203 and related compounds targeting the respiratory cytochrome bc1:aa3. While the cytochrome bc1:aa3 is the primary terminal oxidase in Mycobacterium tuberculosis, the presence of an alternate bd-type terminal oxidase limits the bactericidal and sterilizing potency of Q203 against this bacterium. M. ulcerans strains found in Buruli ulcer patients from Africa and Australia lost all alternate terminal electron acceptors and rely exclusively on the cytochrome bc1:aa3 to respire. As a result, Q203 is bactericidal at low dose against M. ulcerans replicating in vitro and in mice, making the drug a promising candidate for Buruli ulcer treatment.
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Tokar et al. Health Research Policy and Systems (2019) 17:23 https://doi.org/10.1186/s12961-019-0415-4
Against the backdrop of the COVID-19 pandemic, health is receiving unprecedented public and political attention. Yet the fact that climate change also presents us with a health crisis deserves further recognition. From more deaths due to heat stress to increased transmission of infectious diseases, ...climate change affects the social and environmental determinants of health in ways that are profound and far-reaching. The fundamental interdependency of human health and the health of the environment is encapsulated in the concept of planetary health, a scientific field and social movement that has been gaining force since the 2015 publication of the Rockefeller Foundation-Lancet Commission report “Safeguarding human health in the Anthropocene epoch”.
We see an urgent need for strategic communication to raise awareness of climate-health synergies in order to overcome the misperception that climate and health are two independent agendas. The fragmented and sector-focused nature of thinking and action remains a significant barrier to integrating health considerations into climate planning and project development. Inevitably, collaboration across sectors requires a community of practice. Despite recent efforts focused on the climate-health nexus, much work remains to be done to translate scientific findings for policymakers, mobilise climate financing resources in support of health co-benefits, and promote genderjust solutions within climate change projects.
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Independent Monitoring Board of the Global Polio Eradication Initiative (Twelfth Report: October 2015)
EBioMedicine. 2016 Jun 16. pii: S2352-3964(16)30276-6. doi: 10.1016/j.ebiom.2016.06.020. Open Access
Bajo el tema La equidad, el corazón de la salud, este plan procura catalizar los esfuerzos en los Estados Miembros para reducir las inequidades en materia de salud entre los países y los territorios y dentro de ellos, a fin de mejorar los resultados en materia de salud. En el plan se señalan medi...das específicas para abordar la desigualdad en la salud, incluidas las recomendadas de la Comisión sobre Equidad y Desigualdades en Salud en las Américas, y se sigue la orientación de la Comisión de Alto Nivel para la Salud Universal. El enfoque que se adopta en este plan para abordar los determinantes de la salud incluye cuatro temas transversales clave: la equidad, el género, la etnicidad y los derechos humanos
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Der Klimawandel verschärft die Treiber für Migration und Flucht
Zu den ohnehin bestehenden Gründen, die Menschen zum Verlassen ihrer Heimat zwingen, kommt der Klimawandel verschärfend hinzu. Schätzungen zur Rolle des Klimawandels sind wegen der Komplexität des Zusammenspiels verschiedener Mig...rations- oder Fluchtursachen äußerst schwierig. Die Vorhersagen über das mögliche Ausmaß von Migration infolge des Klimawandels gehen daher weit auseinander – bis zum Jahr 2050 könnten zwischen 25 und 700 Millionen Menschen davon betroffen sein (micle 2012).
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Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine | The aim of this study was to explore the risk factors for stillbirth and neonatal death and change in perinatal outcomes after the introduction of helping Babies Breathe Quality Improvement Cycle in Nepal.
Physical distancing measures are important to reduce COVID-19 transmission. However, when stringently applied, they can result in negative health and socio-economic impacts. This report draws on a rapid review of available literature, case studies from across Africa and expert knowledge to make reco...mmendations on adapting classic physical distancing measures to the contextual realities in Africa and on mitigating potential negative impacts.
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BioMed Central DOI 10.1186/s12963-016-0096-y
Urban poor communities including the homeless, residents of informal settlements, residents at risk of being evicted, Internally Displaced Persons (IDPs), undocumented persons, low-income renters, as well as homeowners are perhaps at greatest risk from both COVID-19 and the response interventions to... it.
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