This publication seeks to describe the best treatments and practices based on the scientific evidence available at the time of writing as evaluated by the authors and may change as a result of new research. Readers need to apply this knowledge to patients in accordance with the guidelines and laws o...f their country of practice. Some medications may not be available in some countries and readers should consult the specific drug information since not all the unwanted effects of medications are mentioned.
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Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are... limited to antibiotics with severe side effects. Here, we show that M. ulcerans is susceptible to the anti-tubercular drug Q203 and related compounds targeting the respiratory cytochrome bc1:aa3. While the cytochrome bc1:aa3 is the primary terminal oxidase in Mycobacterium tuberculosis, the presence of an alternate bd-type terminal oxidase limits the bactericidal and sterilizing potency of Q203 against this bacterium. M. ulcerans strains found in Buruli ulcer patients from Africa and Australia lost all alternate terminal electron acceptors and rely exclusively on the cytochrome bc1:aa3 to respire. As a result, Q203 is bactericidal at low dose against M. ulcerans replicating in vitro and in mice, making the drug a promising candidate for Buruli ulcer treatment.
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A paper presented at the 10th International Congress on Infectious Disease, Singapore
Acta Trop. 2020 Mar:203:105289. doi: 10.1016/j.actatropica.2019.105289
The role of malacological surveys to identify potential transmission sites for schistosomiasis control in this era of
mass drug administration have received little attention. In that context, the present study was conducted to
...
determine the abundance, identity and disease transmission potential of intermediate host snails for intestinal
schistosomiasis on Ijinga Island, north-western Tanzania.
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Promising Approaches to Combination HIV Prevention Programming in Concentrated Epidemics
AIDSTAR-One CASE STUDY SERIES May 2010
This document provides interim guidance on the management of the blood supply in response to the pandemic outbreak of coronavirus disease (COVID-19). It emphasizes the importance of being prepared and responding quickly and outlines key actions and measures that the blood services should take to mit...igate the potential risk to the safety and sufficiency of the blood supplies during the pandemic.
It should be read in conjunction with WHO Guidance for National Blood Services on Protecting the Blood Supply During Infectious Disease Outbreaks, which provides general guidance on the development of national plans to respond to any emerging infectious threats to the sufficiency or safety of the blood supply.
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UNAIDS 2016, Reference
HIV care and support taking into account the 2016 WHO consolidated guidelines
Le succès de la mise en œuvre du PNAPF 2017-2020 dépendra de l’engagement de chaque entité à tous les niveaux à travers des arrangements institutionnels clairs. Il s’agit d’un document dynamique qui requerra une forte coordination des différentes parties prenantes multisectorielles. La ...mise en œuvre sera conduite par le Ministère de la Santé à travers la Direction de la Santé de la Famille (DSF). Les autres secteurs tels que les ministères connexes contribueront à favoriser l’environnement juridique et politique de la PF pour garantir l’accès de tous, notamment des jeunes aux services de PF. Les organisations de la société civile (OSC) et les PTF apporteront leur contribution à la mise en œuvre du plan, au renforcement des
capacités des acteurs en PF, au plaidoyer et à la mobilisation des ressources pour la pérennité du programme.
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This guide assumes the reader already has a general understanding of the Care Group methodology. It is highly recommended that all Care Group implementers familiarize themselves with the contents of theCare Groups: A Training Manual for Program Design and Implementation,and, ideally,to participate i...n an in-person training on Care Groups, before commencing Care Group activities. This guide is meant to serve as a companion to the Care Group Training Manual; and additional details on all topics covered in this guide are provided in the Training Manual. This guide may also be used by program evaluators, as a means to assess the extent to which Care Groups were implemented in accordance with theevidence-based model and their potential contribution to program outcomes.
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Médecins sans Frontières access campaign
Issue Brief
Accessed: 28.11.2019
PLOS ONE | www.plosone.org
September 2014 | Volume 9 | Issue 9 | e103657
A new report from aid agencies Age International and HelpAge International, If not now, when? criticises the humanitarian sector for its failure to address the needs of older people in emergencies. This failure contravenes several international commitments made in recent years and flies in the face ...of humanitarian principles
Download the full report here: https://www.helpage.org/download/5fb34a78e7597/
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