This document is the third iteration of the Flash Appeal for Ukraine, which was originally published on 1 March 2022 and revised once in mid-April. This updated Flash Appeal covers the period of 10 months following the onset of the war in Ukraine that started on 24 February 2022 (i.e., from March to... December 2022). The financial requirement of this Flash Appeal reflects the humanitarian needs from March until the end of 2022, taking into account the funding status and the response achievements to date, as well as the realistic projection of response capacity in the second half of the year.
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Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are... limited to antibiotics with severe side effects. Here, we show that M. ulcerans is susceptible to the anti-tubercular drug Q203 and related compounds targeting the respiratory cytochrome bc1:aa3. While the cytochrome bc1:aa3 is the primary terminal oxidase in Mycobacterium tuberculosis, the presence of an alternate bd-type terminal oxidase limits the bactericidal and sterilizing potency of Q203 against this bacterium. M. ulcerans strains found in Buruli ulcer patients from Africa and Australia lost all alternate terminal electron acceptors and rely exclusively on the cytochrome bc1:aa3 to respire. As a result, Q203 is bactericidal at low dose against M. ulcerans replicating in vitro and in mice, making the drug a promising candidate for Buruli ulcer treatment.
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Guia de treinamento para profissionais de saúde da linha de frente
Versão oficial em português da obra original em Inglês
Recognizing neglected tropical diseases through changes on the skin: a training guide for front-line health workers
Lessons from the IRC’s Early Emergency Response in the Urban Areas of Lesbos between September 2015 and March 2016
In its report from 2014, the Working Group outlines the various factors influencing vaccine acceptance or refusal, and what can be done to create social norms around vaccine acceptance and to encourage the general public regarding the necessity of vaccination.
The World Heart Federation (WHF) commenced a Roadmap initiative in 2015 to reduce the global burden of cardiovascular disease and resultant burgeoning of healthcare costs. Roadmaps provide a blueprint for implementation of priority solutions for the principal cardiovascular diseases leading to death... and disability. Atrial fibrillation (AF) is one of these conditions and is an increasing problem due to ageing of the world’s population and an increase in cardiovascular risk factors that predispose to AF. The goal of the AF roadmap was to provide guidance on priority interventions that are feasible in multiple countries, and to identify roadblocks and potential strategies to overcome them.
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Asbestos, the most frequent cause of occupational cancer, continues to be consumed ona massive scale, with millions of people exposed on a daily basis. This review explains why we havefailed in curtailing the silent epidemic of asbestos-related disease and why the numbers of asbestosvictims are like...ly to remain high. Emerging and developed countries have to be reminded that asbestosexposure has yet to become a problem of the past. The worldwide spread of asbestos, followed by thesurge of asbestos-related cancers, resembles the lung cancer epidemic caused by smoking andstimulated by manufacturers.
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As part of the new strategy preparation, USAID/Senegal requested assistance with a gender assessment. This study was conducted from March 20 to April 11, 2010. It was supported jointly by the Women in Development Indefinite Quantity Contract (WID IQC) Task Order 1 ShortTerm Technical Assistance and ...Training (STTA&T) and the USAID/Senegal mission. In addition to conducting a literature review, the team made site visits in the cities and towns of Dakar, Thiès, Kaolack, and Tambacounda and villages near each of them. These offered examples of key gender issues in Senegal, including gender disparities in access to education, unequal allocation of land and other productive resources, and gender-based violence (such as domestic violence, female genital cutting [FGC], and rape), as well as examples of USAID/Senegal‟s programming to address these problems.
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At the World Humanitarian Summit in Istanbul in May 2016, leaders made over 3,700 commitments to advance the Agenda for Humanity. In their first self-reports against these commitments, 142 stakeholders described the efforts they made from June to December 2016 to realize this ambitious vision.
The ...2017 annual synthesis report on progress provides a summary of their collective achievements around the 5 Core Responsibilities and 24 Transformations of the Agenda for Humanity.
Executive summary in
English: https://www.agendaforhumanity.org/sites/default/files/asr/2017/Nov/No%20time%20to%20retreat%20Executive%20Summary_NEW_web_nov27.pdf;
French: https://www.agendaforhumanity.org/sites/default/files/asr/2018/Jan/No%20time%20to%20retreat_Executive%20summary_FRENCH_Final_web.pdf
Spanish: https://www.agendaforhumanity.org/sites/default/files/asr/2018/Jan/No%20time%20to%20retreat_Executive%20summary_Spanish_final_web.pdf
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South Africa reported it fist case of COVID-19 on 5 March 2020. While the first cases were imported, local transmission has led to a rapid increase in the number of cases. As of 21 April 2020, more than 3,400 cases and 58 deaths had been confirmed. On 15 March, President Cyril Ramaphosa declared a n...ational state of disaster, and the government has since taken several measures to curb the spread of the virus, including closing borders, implementing strict social distancing measures and a 35-day nation-wide lockdown. These measures, along with the global economic shock caused by the pandemic, are expected to generate rising needs requiring an immediate and urgent response. Although South Africa is considered an upper-middle-income country, the amount of disparities—social, economic, and gender—make the country particularly vulnerable during this emergency.
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This guide has been produced by the International
Network on Explosive Weapons (INEW) to introduce the
humanitarian advocacy agenda on the use of explosive
weapons in populated areas and to provide ideas for actions
at the national level. It is aimed primarily at NGOs and
campaigners worki...ng on humanitarian issues and issues
related to weapons and protection of civilians.
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Internal displacement at all-time high after unprecedented year of crises
The total number of people living in internal displacement reached a record 55 million by the end of 2020. During a year marked by intense storms and persistent conflict, 40.5 million new displacements were triggered across... the world by disasters and violence, the highest annual figure recorded in a decade.
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The ‘Toolkit’ is targeted at practitioners responsible for implementing recovery programmes, their objective to provide a ‘how to’ guide on development, implementing and managing complex post-disaster recovery programmes.
Disaster Recovery Toolkit
In the last quarter of 2019 Southern African Regional Interagency Standing Committee Africa (RIASCO) reported that more than 11 million people were experiencing crisis or emergency levels of food insecurity in nine Southern African countries1 due to deepening drought and climate related crisis. The ...Southern African Development Community (SADC) urged for urgent humanitarian action, and at the beginning of November 2019 Angola, Botswana, Lesotho and Namibia had declared states of drought emergencies, requiring international assistance to address the worsening food insecurity situation.
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From Participation to Partnerships (September 2020)
Despite the COVID-19 challenges, children around the world have found meaningful ways to support and protect their peers, families, and communities. Children are on the frontlines of innovative responses and are working closely with their adult al...lies. The leadership demonstrated through these child-adult partnerships is the underlying inspiration for this guide.
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4. Central African Republic
Clashes throughout 2018 in the capital Bangui and a number of major towns illustrate the deadly threat posed by armed groups – a mix of pro-government militias, ex-rebels, bandits and local “self-defence” units – that control much of the countr...y. MINUSCA, the UN peacekeeping force, has failed to neutralise these groups and, as a result, is mistrusted by the general public. Likewise, the national army, slowly being deployed in parts of the country, has been unable to constrain the armed groups’ predatory activities. The humanitarian situation remains dire, with more than one million people internally displaced or fleeing to neighbouring countries and 2.5 million in need of assistance, according to the UN.
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Recommendations to develop guidelines on community-based rehabilitation (CBR) were made during the International Consultation to Review Community-based Rehabilitation which was held in Helsinki, Finland in 2003. WHO; the International Labour Organization; the United Nations Educational, Scientific ...and Cultural Organization; and the International Disability and Development Consortium – notably CBM, Handicap International, the Italian Association Amici di Raoul Follereau, Light for the World, the Norwegian Association of Disabled and Sightsavers – have worked closely together to develop the Community-based rehabilitation guidelines. More than 180 individuals and representatives of nearly 300 organizations, mostly from low-income and middle-income countries around the world, have been involved in their development.
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The present report is submitted pursuant to Security Council resolution 2164 (2014), by which the Council extended the mandate of the United Nations Multidimensional Integrated Stabilization Mission in Mali (MINUSMA) and requested me to report to it every three months on the implementation of the re...solution and the progress on the implementation of the Mission’s mandate. The present report covers the period from 17 December 2014 to 19 March 2015.
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Fills a gap in current guidance on how to implement humanitarian standards in urban situations. In Arabic, English, French and Spanish available
สื่อ “สาร” ให้เข้าถึง : คู่มือนักข่าวส าหรับการรายงานเกี่ยวกับการเปลี่ยนแปลงสภาพภูมิอากาศและการพัฒนาอย่า...งยั่งยืนในภูมิภาคเอเชียและแปซิฟิก
A new, free handbook, for journalists reporting climate change in Asia and the Pacific
It explores the essential aspects of climate change, including its injustices to vulnerable communities, especially women and girls and least developed countries, and provides examples of best practices and stories of hope unique to the region. It can be used as a resource for journalists to understand the science of climate change, as well as helping journalists to improve their reporting of the environmental, social, economic, political, technological and other angles of the story.
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