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Chemoprevention is the use of medicines, either alone or in combination, to prevent malaria infection and its consequences. This publication provides standardized approaches for monitoring and evalu
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ating the efficacy of medicines used for intermittent preventive treatment of malaria in pregnancy, perennial malaria chemoprevention (formerly known as intermittent preventive treatment of malaria in infants), seasonal malaria chemoprevention and intermittent preventive treatment of malaria in school-aged children. It follows the recent release of new and updated WHO recommendations on these interventions.
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Pneumonia kills more children than any other illness – more than AIDS, malaria and measles combined. Over 2 million children die from pneumonia e
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ach year, accounting for almost 1 in 5 under five deaths worldwide. Yet, little attention is paid to this disease. This joint UNICEF/WHO report examines the epidemiological evidence on the burden and distribution of pneumonia and assesses current levels of treatment and prevention. It is a call to action to reduce pneumonia mortality, a key step towards the achievement of the millennium development goal on child mortality.
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This position paper supersedes the 2022 WHO position paper on malaria vaccines. It includes the updated WHO recommendations on the use of the RTS,S/AS01 and R21/Matrix-M vaccines for the reduction of malar
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ia morbidity and mortality in children living in endemic areas, prioritizing areas of moderate and high malaria transmission.
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The CDC's "Malaria's Impact Worldwide" webpage provides an overview of malaria's global burden, highlighting that in 2022, there were approximat
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ely 249 million malaria cases and 608,000 deaths, predominantly among young children in sub-Saharan Africa. It emphasizes that nearly half the world's population is at risk, with malaria being a leading cause of illness and death in many affected countries. The page also discusses the significant economic and social costs of malaria on individuals, families, communities, and nations. Despite progress in reducing mortality rates by 36% from 2010 to 2020, recent years have seen a plateau in advancements, underscoring the need for ongoing vigilance and research.
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The '100 Health Messages for Children to Learn & Share' is an educational resource developed by Children for Health. It is aimed at children aged 8
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–14, particularly young adolescents (aged 10–14), who often care for younger siblings. The set contains 100 simple, accurate and adaptable health messages, with 10 messages on each of the following topics: Malaria, diarrhoea, nutrition, coughs and colds, intestinal worms, water and sanitation, immunisation, HIV and AIDS, accidents and injuries, and early childhood development. The messages have been reviewed by medical and education experts and are designed for use by parents, teachers and health workers in schools, homes, clinics and clubs. The resource encourages active learning through memorisation, discussion, and creative activities, empowering children to become health educators in their communities.
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BioDrugs. 2023 Sep 20;37(6):737–756. doi: 10.1007/s40259-023-00623-4
There are many malaria vaccine candidates in development, with more than a dozen of these
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in clinical development. RTS,S/AS01 (also known as Mosquirix) is the most advanced malaria vaccine and was shown to have modest efficacy against clinical malaria in phase III trials in 5- to 17-month-old infants. Following pilot implementation trials, the World Health Organisation has recommended it for use in Africa in young children who are most at risk of infection with P. falciparum, the deadliest of the human malaria parasites.
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The 2024 World Malaria Report shows that the malaria burden remains overwhelmingly concentrated in Africa. The continent accounted for 94% of globa
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l cases and 95% of malaria-related deaths in 2023. Although the number of malaria cases increased globally from 204 million in 2000 to 246 million in 2023, the number of deaths declined from 805,000 to 569,000. Children under five are still the most affected group, accounting for 76% of malaria deaths in Africa. A few countries, particularly Nigeria and the Democratic Republic of the Congo, carry the highest burden. Since 2000, Africa has significantly reduced malaria incidence and mortality, averting over 1.7 billion cases and 12 million deaths. Nevertheless, malaria continues to pose a significant health challenge, necessitating ongoing action and investment.
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The WHO website titled "Malaria" provides a comprehensive overview of malaria, a potentially fatal disease caused by Plasmodium parasites and primarily transmitted through mosquito bites
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in tropical countries. It offers information on symptoms, at-risk groups, preventive measures, and treatment options. The site also presents recent statistics: in 2023, an estimated 263 million malaria cases and 597,000 deaths occurred in 83 countries, with the African region being the most affected—accounting for 94% of cases and 95% of deaths. Children under the age of five made up approximately 76% of the deaths in this region.
more
The WHO website titled "Malaria" provides a comprehensive overview of malaria, a potentially fatal disease caused by Plasmodium parasites and primarily transmitted through mosquito bites
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in tropical countries. It offers information on symptoms, at-risk groups, preventive measures, and treatment options. The site also presents recent statistics: in 2023, an estimated 263 million malaria cases and 597,000 deaths occurred in 83 countries, with the African region being the most affected—accounting for 94% of cases and 95% of deaths. Children under the age of five made up approximately 76% of the deaths in this region.
more
The WHO website titled "Malaria" provides a comprehensive overview of malaria, a potentially fatal disease caused by Plasmodium parasites and primarily transmitted through mosquito bites
...
in tropical countries. It offers information on symptoms, at-risk groups, preventive measures, and treatment options. The site also presents recent statistics: in 2023, an estimated 263 million malaria cases and 597,000 deaths occurred in 83 countries, with the African region being the most affected—accounting for 94% of cases and 95% of deaths. Children under the age of five made up approximately 76% of the deaths in this region.
more
The MSF malaria guidelines provide practical, evidence-based recommendations for diagnosing, treating, and preventing malaria, especially in low-re
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source settings. They cover uncomplicated and severe cases, recommend rapid tests and artemisinin-based therapies, and include special guidance for vulnerable groups like children and pregnant women.
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The Zambia Malaria Campaign, implemented by Breakthrough ACTION, used culturally tailored radio adverts and a campaign song to encourage key behaviours for preventing and treating malaria. The campa
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ign targeted high-risk groups, such as pregnant women and caregivers of children under five, and delivered messages in multiple local languages, including English, Siswati and Tonga. The audio content encouraged the consistent use of insecticide-treated nets (ITNs), seeking timely care for fevers, and preventing malaria during pregnancy. Through addressing common myths and promoting positive social norms in an engaging way, the campaign aimed to increase community knowledge and encourage long-lasting behavioural change in malaria-endemic regions of Zambia.
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While there has been real progress in addressing the burden of disease in the WHO African region, the COVID-19 pandemic has highlighted the link between health, economics and security, as the region
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saw decades of progress threatened, including positive trends in decreasing inequality. In the African Region the momentum towards achieving the 2030 SDG disease burden reduction targets (SDG targets 3.3, 3.4 and 3B) has stalled.
The COVID-19 pandemic was also a major threat to gains made, such as the eradication of polio in the region, declared in 2020; reduced numbers of new HIV infections in 2021 compared to 2010; and passing the 2020 milestone of the End TB Strategy, with a 22% reduction in new cases compared with 2015. However, the pandemic also disrupted essential health services in 92% of countries globally, 22.7 million children missed basic immunization, there was an increase in malaria and TB, and global deaths from TB rose for the first time since 2015.
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Pocket book of hospital care for children
recommended
Guidelines for the Management of common childhood Illness. 2nd edition
These guidelines focus on the management of the major causes of childhood mortality in most developing countries, such as newborn problems, pneumonia, diarrhoea,
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malaria, meningitis, septicaemia, measles and related conditions, severe acute malnutrition and paediatric HIV/AIDS. It also covers common procedures, patient monitoring and supportive care on the wards and some common surgical conditions that can be managed in small hospitals.
A smart phone and tablet application is available from the Apple or Google Play Store.
Special attention is drawn to the following sections, which are particulary relevant within the COVID-19 context:
Chapter 4: information on cough and difficulty in breathing, pneumonia and bronchiolitis;
Chapter 10: information on essential supportive care including feeding, fluid and oxygen provision;
Annex 1: information on related practical procedures.
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WASH 4 All 1 is an educational comic designed to raise awareness of water, sanitation and hygiene practices. Through engaging illustrations and simple language, it educates communities, especially children and families, about the importance of clean
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water, proper sanitation and good hygiene in improving health outcomes. The booklet is a practical tool that can be used by educators and health promoters to encourage behavioural change in a variety of settings.
Accessed on 20/06/2025.
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Lancet Glob Health 2019 Published Online January 24, 2019 http://dx.doi.org/10.1016/S2214-109X(18)30479-0
The health-care system collapse underway in Venezuela is a cause of utmost concern for its people and, increasingly, for the wider region
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. Declines in provision of basic services, such as childhood immunisation, malaria control, water, sanitation, and nutritional support, have led to increasing morbidity and mortality rates from an array of preventable diseases, including malaria, measles, and diphtheria. Secondary and tertiary care have also been greatly affected, due to declining investment, out-migration of providers, and spiralling hyperinflation that has driven the country and its people into poverty.1 As is so often, and so tragically, the case, the most affected populations have been the most vulnerable: infants and children, their mothers, the poor (now the great majority of the populations), and indigenous people
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Pregnant travelers face numerous risks, notably increased susceptibility to or severity of multiple infections, including malaria. Because pregnant women residing in areas non-endemic for
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malaria are unlikely to have protective immunity, travel to endemic areas poses risk of severe illness and pregnancy complications, such as low birthweight and fetal loss. If travel to malaria-endemic areas cannot be avoided, preventive measures are critical. However, malaria chemoprophylaxis in pregnancy can be challenging, since commonly used regimens have varying levels of safety data and national guidelines differ. Furthermore, although chloroquine and mefloquine have wide acceptance for use in pregnancy, regional malaria resistance and non-pregnancy contraindications limit their use. Mosquito repellents, including N,N-diethyl-m-toluamide (DEET) and permethrin treatment of clothing, are considered safe in pregnancy and important to prevent malaria as well as other arthropod-borne infections such as Zika virus infection. Pregnant travelers at risk for malaria exposure should be advised to seek medical attention immediately if any symptoms of illness, particularly fever, develop.
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This video highlights the significant risks that malaria poses to pregnant and breastfeeding women in malaria-endemic regions. It follows the stori
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es of Angavu from Kenya, Moyinoluwa from Nigeria and Lamai from Thailand. It emphasises the severe consequences that malaria can have during pregnancy, including miscarriage, stillbirth, low birth weight and maternal death. Due to safety concerns, pregnant women are often excluded from antimalarial drug trials, which causes long delays in effective medicines becoming available for this vulnerable group. To address this issue, the Medicines for Malaria Venture (MMV) launched the Malaria in Mothers and Babies (MiMBa) initiative, which aims to accelerate the discovery, development, and delivery of safe antimalarial treatments for pregnant and breastfeeding women. The initiative aims to close critical gaps in research, drug development, and access, ensuring that these women and their babies are better protected against malaria. The video calls for continued efforts to address the needs of underserved populations most affected by malaria.
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Health Situation of Children in Southern Africa
The impacts of El Niño and La Niña are expected to more than double the regular caseloads of childhood illnesses (
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malaria, cholera, pneumonia, measles and diarrhoea) in the most affected countries.
• Diarrhoea cases among children are expected to increase up to 4 times that of the regular yearly cases.
• Projections of pneumonia cases among children show a 1.5 times increase in cases.
• An estimated 11.8 million children are likely to be affected by malaria, cholera, diarrhoea, measles and/or pneumonia, with 7.5 million of these cases directly related to the impacts of El Nino.
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Breaking Barriers is an implementation research project focusing on social and behavioural change. It is conducted in conflict-affected communities in Cameroon. The project explores three innovative
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, community-based interventions designed to improve health behaviours. This presentation outlines the project's context, methodology and implementation process. It also shares qualitative insights and field perspectives, reflecting on key lessons learned for future SBC efforts in fragile settings.
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