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Of the 50 antibiotics in the pipeline, 32 target WHO priority pathogens but the majority have only limited benefits when compared to existing antibiotics. Two of these are active against the multi-drug resistant Gram-negative bacteria, which are spreading rapidly and require urgent solutions.
Gr
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am-negative bacteria, such as Klebsiella pneumoniae and Escherichia coli, can cause severe and often deadly infections that pose a particular threat for people with weak or not yet fully developed immune systems, including newborns, ageing populations, people undergoing surgery and cancer treatment.
The report highlights a worrying gap in activity against the highly resistant NDM-1 (New Delhi metallo-beta-lactamase 1), with only three antibiotics in the pipeline. NDM-1 makes bacteria resistant to a broad range of antibiotics, including those from the carbapenem family, which today are the last line of defence against antibiotic-resistant bacterial infections.
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Cities can help nations achieve their Paris Agreement commitment by supporting the implementation of transformational actions to increase the supply of renewable energy, improve building energy efficiency, increase access to affordable, low carbon transport options, and change consumption patterns.
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Seventy per cent of C40 cities report that they are already experiencing the impacts of climate change. Cities need to adapt and improve their resilience to climate hazards that may impact them, both in the short-term and in future climate change scenarios. Cities are already leading the way with ambitious plans to accelerate action on climate change. With more political will, community support and collaboration, cities can make an even greater contribution to securing a climate safe future.
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Vaincre le Sida par Tous, une Riposte pour Tous
Le Plan Stratégique National de Lutte contre le Sida (PSN) 2018-2022 sera le cadre unique pour tous les acteurs de la lutte contre le sida au Sénégal. Il constitue la référence pour la programmation des activités aux niveaux national et régio
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nal, et sera l’outil indispensable pour l’harmonisation et l’alignement des partenaires. Ce plan traduit la vision et les engagements du Gouvernement du Sénégal à maintenir les acquis et à orienter la riposte vers l’élimination du sida en utilisant toutes les opportunités et ressources, aussi bien domestiques qu’internationales.
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Senegal’s substantial and sustained progress against malaria is an inspiring public health success story, and a source of potential lessons for other countries on the path to elimination. This case study describes three major success factors—(1) outstanding leadership and partner engagement, (2)
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the achievement and maintenance of high intervention coverage levels, and (3) a thriving data culture—and explores several exciting new opportunities to consolidate and expand upon Senegal’s two decades of impact.
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Près de deux ans après la signature de l’Accord Politique pour la Paix et la Réconciliation (APPR), la population centrafricaine est toujours l’otage d’un environnement sécuritaire instable et imprévisible. La poursuite des conflits dans plusieurs zones du pays, les faiblesses structurell
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es conjuguées aux effets socio-économiques de la pandémie de COVID-19 et aux effets dévastateurs des catastrophes naturelles ont plongé 2,8 millions de personnes dans une grande vulnérabilité. Sur ce total, 1,9 million connaissent des besoins humanitaires sévères, un chiffre inégalé depuis 5 ans qui traduit une détérioration du bien-être physique et mental et des conditions de vie des populations dans l’ensemble du pays.
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El fenómeno mundial de la Resistencia a los Antimicrobianos (RAM), es actualmente la principal amenaza para la salud pública en el siglo XXI, alcanzando proporciones preocupantes en todas las regiones del mundo. A su vez está poniendo en riesgo la sostenibilidad de los sistemas agroalimentarios y
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con ello, la seguridad alimentaria y el comercio de alimentos
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Les progrès substantiels et soutenus du Sénégal dans la lutte contre le paludisme constituent une réussite exemplaire en matière de santé publique et une source d’enseignements potentiels pour d’autres pays sur la voie de l’élimination. Ce document décrit trois facteurs principaux de s
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uccès :(1) un leadership exceptionnel et un fort engagement des partenaires, (2) l’atteinte et le maintien de niveaux élevés de couverture des interventions, et (3) la promotion d’une culture d’utilisation des données; et explore plusieurs nouvelles opportunités prometteuses pour consolider et amplifier les succès des deux dernières décennies.
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Senegal has adopted the World Health Organization’s (WHO’s) three-pronged strategy for combating malaria in pregnancy (MiP): (1) intermittent preventative treatment in pregnancy (IPTp)1 via directly observed therapy (DOT), (2) distribution and use of insecticidetreated nets (ITNs), and (3) case
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management of MiP. The country began implementing IPTp in 2003.2 Senegal’s National Malaria Control Program (NMCP) has shown strong leadership in supporting key malaria interventions. 3
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Each year, 33000 people die from an infection due to bacteria resistant to antibiotics. The burden of infections with bacteria resistant to antibiotics on the European population is comparable to that of influenza, tuberculosis and HIV/AIDS combined.
A patient leaflet for primary care prescribers to hand out to patients: it explains to patients what antibiotic resistance is and why appropriate use of antibiotics is important.
The World Health Organization (WHO) recommends the use of insecticide-treated nets (ITNs) and intermittent preventive treatment in pregnancy (IPTp) as a cost-effective intervention for the prevention of malaria during pregnancy in endemic areas. This study was conducted to investigate: (1) the exten
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t of use of both IPTp and ITNs, and (2) conduct multinomial regression to identify factors affecting the optimal usage of IPTp and ITNs among women with a recent pregnancy in Senegal.
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BMJ Global Health Vol.4 (2019 no.4
The Drug Resistance Index (DRI) is proposed as measure of antibiotic effectiveness in a given country, by combining, in a single metric the use of various antibiotic groups and the resistance proportions of several pathogens.It is a complicated measure that gives
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results that cannot be understood by common knowledge and logic. The DRI conveys a wrong message.
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Infection prevention and control Online Course
recommended
Infection Prevention and Control (IPC) is a major challenge for health care systems around the world. There is an important opportunity to reduce avoidable morbidity and mortality through improvements to IPC.
The IPC channel hosts general materials designed for all health workers, as well as more
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advanced materials specific to IPC focal points. The goal is to strengthen health workers' IPC knowledge and advance the IPC focal points’ capacity to implement facility-led IPC efforts.
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Market and technology landscape HIV rapid diagnostic tests for self-testing
O. Ajose; C. Pérez Casas; H. Ingold; et al.
Unitaid (Innovation in Global Health); World Health Organization (WHO)
(2018)
C2
4th edition
The Global Fund is a worldwide partnership to defeat AIDS, tuberculosis (TB) and malaria and ensure a healthier, safer and more equitable future for all. We raise and invest up to US$5 billion a year to fight deadly infectious diseases, challenge the injustice that fuels them, and strengthen health
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and community systems in more than 100 of the hardest hit countries.
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Belgian Antibiotic Policy Coordination Committee Policy paper for the 2014-2019 term
Erica Balligand, Michiel Costers and Evelyne Van Gastel
Belgian Antibiotic Policy Coordination Committee
(2014)
C2
Antimicrobial resistance represents a big threat to public health. The Centers for Disease Control and Prevention (CDC) estimate that every year two million Americans are infected with a (multi-)drug resistant bacterium, resulting in 23,000 deaths. The WHO has repeatedly drawn attention to this majo
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r health issue. In the worst-case scenario, we will shortly run out of effective antibiotics. Surgery and cancer therapy will then become very dangerous due to the risk of infection associated with such treatments. (Organ) transplantation will become close to impossible as the immunosuppression necessary for transplant patients makes them highly vulnerable to infections. Some infections we can easily treat today could turn deadly. It is therefore conceivable that infectious diseases once again become the leading cause of death as in early 20th century.
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