PLOS ONE | https://doi.org/10.1371/journal.pone.0217693 June 7, 2019
Psychiatry and Pediatrics
Chapter I.5
Editorial Review
AIDS 2019, 33:1411–1420
PLOS Medicine | www.plosmedicine.org
January 2013 | Volume 10 | Issue 1 | e1001371
December 2015
National guidelines for of Clubfoot
4th Edition 2018
National Malaria Elimination & Aedes Transmitted Disease Control Program
Disease Control Unit Directorate General of Health Services
A guide to protocol development for low-income countries
PNAS 119 (8) e2113947119 | https://doi.org/10.1073/pnas.2113947119
Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, m...easure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the scale of the problem from a global perspective. Furthermore, comparison of the existing data, generated for different studies/regions/continents, is challenging due to the vast differences between the analytical methodologies employed. Here, we present a global-scale study of API pollution in 258 of the world’s rivers, representing the environmental influence of 471.4 million people across 137 geographic regions. Samples were obtained from 1,052 locations in 104 countries (representing all continents and 36 countries not previously studied for API contamination) and analyzed for 61 APIs. Highest cumulative API concentrations were observed in sub-Saharan Africa, south Asia, and South America. The most contaminated sites were in low- to middle-income countries and were associated with areas with poor wastewater and waste management infrastructure and pharmaceutical manufacturing. The most frequently detected APIs were carbamazepine, metformin, and caffeine (a compound also arising from lifestyle use), which were detected at over half of the sites monitored. Concentrations of at least one API at 25.7% of the sampling sites were greater than concentrations considered safe for aquatic organisms, or which are of concern in terms of selection for antimicrobial resistance. Therefore, pharmaceutical pollution poses a global threat to environmental and human health, as well as to delivery of the United Nations Sustainable Development Goals.
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PlosOne December 10, 2014 https://doi.org/10.1371/journal.pone.0111913
Plastic pollution is ubiquitous throughout the marine environment, yet estimates of the global abundance and weight of floating plastics have lacked data, particularly from the Southern Hemisphere and remote regions. Here we re...port an estimate of the total number of plastic particles and their weight floating in the world's oceans from 24 expeditions (2007–2013) across all five sub-tropical gyres, costal Australia, Bay of Bengal and the Mediterranean Sea conducting surface net tows (N = 680) and visual survey transects of large plastic debris (N = 891). Using an oceanographic model of floating debris dispersal calibrated by our data, and correcting for wind-driven vertical mixing, we estimate a minimum of 5.25 trillion particles weighing 268,940 tons. When comparing between four size classes, two microplastic <4.75 mm and meso- and macroplastic >4.75 mm, a tremendous loss of microplastics is observed from the sea surface compared to expected rates of fragmentation, suggesting there are mechanisms at play that remove <4.75 mm plastic particles from the ocean surface.
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Sleeping sickness is controlled by case detection and treatment but this often only reaches less than 75% of the population. Vector control is capable of completely interrupting HAT transmission but is not used because of expense. We conducted a full scale field trial of a refined vector control tec...hnology. From preliminary trials we determined the number of insecticidal tiny targets required to control tsetse populations by more than 90%. We then carried out a full scale, 500 km2 field trial covering two HAT foci in Northern Uganda (overall target density 5.7/km2). In 12 months tsetse populations declined by more than 90%. A mathematical model suggested that a 72% reduction in tsetse population is required to stop transmission in those settings. The Ugandan census suggests population density in the HAT foci is approximately 500 per km2. The estimated cost for a single round of active case detection (excluding treatment), covering 80% of the population, is US$433,333 (WHO figures). One year of vector control organised within country, which can completely stop HAT transmission, would cost US$42,700. The case for adding this new method of vector control to case detection and treatment is strong. We outline how such a component could be organised.
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PLOS ONE | DOI:10.1371/journal.pone.0142290 November 9, 2015; 1 / 16
The pharmacological management of asthma has changed considerably in recent decades, as it has come to be understood that it is a complex, heterogeneous disease with different phenotypes and endotypes. It is now clear that the goal of asthma treatment should be to achieve and maintain control of the... disease, as well as to minimize the risks (of exacerbations, disease instability, accelerated loss of lung function, and adverse treatment effects). That requires an approach that is personalized in terms of the pharmacological treatment, patient education, written action plan, training in correct inhaler use, and review of the inhaler technique at each office visit. A panel of 22 pulmonologists was invited to perform a critical review of recent evidence of pharmacological treatment of asthma and to prepare this set of recommendations, a treatment guide tailored to use in Brazil. The topics or questions related to the most significant changes in concepts, and consequently in the management of asthma in clinical practice, were chosen by a panel of experts. To formulate these recommendations, we asked each expert to perform a critical review of a topic or to respond to a question, on the basis of evidence in the literature. In a second phase, three experts discussed and structured all texts submitted by the others. That was followed by a third phase, in which all of the experts reviewed and discussed each recommendation. These recommendations, which are intended for physicians involved in the treatment of asthma, apply to asthma patients of all ages.
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Manuel destiné au personnel de santé. Le présent manuel est un guide spécialisé sur les techniques et les méthodes de laboratoire à utiliser pour le diagnostic de l’ulcère de Buruli, une maladie provoquée par Mycobacterium ulcerans. Destiné aux techniciens et aux scientifi ques de labora...toire travaillant sur cette maladie, le présent manuel décrit les méthodes exactes à mettre en oeuvre pour réaliser un certain nombre de tests diagnostiques. Les procédures recommandées, utilisables dans l’ensemble du système de santé, sont adaptées aux services périphériques, des districts et centraux et ce, conformément aux ressources, compétences et matériel variables que l’on trouve classiquement dans les pays où l’ulcère de Buruli est endémique.
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Chaque année, des milliers d’enfants béninois meurent ou n’arrivent pas à développer pleinement leur potentiel physique ou intellectuel du fait de la malnutrition chronique. La présente politique du secteur de la santé pour la nutrition se focalise sur la mère, lenourrisson,... l’enfant et l’adolescent et prend en compte les résolutions du récent forum national organisé à Cotonoudu 11 au 13 juin 2015, par le Conseil National de l’Alimentation et de la Nutrition(CAN)sur la lutte contre la malnutrition chronique axée sur la fenêtre d’opportunité des 1000 premiers jours de la vie (allant de la conception à la fin de la deuxième année de vie). Elle se fonde sur les principes d’équité?d’éthique et de transparence dans la gestion des problèmes nutritionnels.Cette politique est l’œuvre de la Direction de la Santé de la Mère et de l’Enfant (DSME) avec le soutien technique et financier de l’Organisation Mondiale de la Santé (OMS). Elle servira au cours des dix prochaines années (2016-2025) d’orientation à tous les acteurset partenaires qui contribuent à l’amélioration de l’état nutritionnel des cibles visées.
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Curricular Modules for Lecturers and Teachers.
The 2nd edition of the Global Public Health Curriculum has been published in the South Eastern European Journal of Public Health, end of 2016 as a special volume . The curriculum targets the postgraduate education and training of public health professi...onals including their continued professional development (CPD). However, specific competences for the curricular modules remained to be identified in a more systematic approach
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Recent systematic reviews and meta-analysis of the impact of chemical-based mollusciciding (King et al., 2015, Sokolow et al., 2016) have concluded that regular mollusciciding is likely to contribute significantly towards elimination of schistosomiasis in high-risk areas. The WHO roadmap’s new foc...us on “transmission control, wherever possible” (WHO, 2012a) reinforces the need to promote intermediate-host snail control to prevent schistosomiasis transmission.
This operational manual is intended to facilitate the reintroduction of practices and protocols for use of molluscicides in the field in schistosomiasis control programmes. It is complemented by guidelines on the laboratory and field testing of the efficacy of molluscicides for schistosomiasis control (WHO, 2017 [in preparation]).
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Transformer les managers en leaders donne aux responsables de la santé à tous les niveaux d'une organisation les moyens de diriger des équipes pour relever des défis et obtenir des résultats. Il répond à des questions telles que : Comment puis-je diriger et gérer plus efficacement ? Comment ...créer une vision partagée et une voie claire pour y parvenir ? Que puis-je faire pour améliorer le climat de travail ? Comment puis-je me préparer et préparer les autres à des niveaux de responsabilité plus élevés ? Comment conduire le changement à l'intérieur et à l'extérieur de mon organisation ?
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Zanoni BC, et al. BMJ Glob Health 2016;1:e000004. doi:10.1136/bmjgh-2015-000004
La crise humanitaire que traverse la Centrafrique demeure complexe. Un total de 621 035 personnes sont déplacées à l’intérieur du pays et 572 984 personnes dans les pays voisins à la fin du mois d’août 2018. Le nombre de personnes dans le besoin est passé de 2,5 millions à 2,9 millions d...ont 1,6 million en besoin d’assistance aiguë et immédiate, soit une augmentation de 16% par rapport à l’année 2017. Cette augmentation est la conséquence directe de la multiplication des foyers de conflit dans plusieurs régions du pays, du nombre croissant d’incidents sécuritaires affectant les civils et les humanitaires, et du manque de ressources nécessaires qui mettent en péril les efforts de restauration des services de base. Les conséquences humanitaires de cette crise sont ressenties dans les domaines de la protection, du déplacement forcé des populations et de l’accès aux services sociaux de base.
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