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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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The increasing burden of asthma in South African children: A call to action

Masekela, R.; Gray, C.L.; Green, R.J. et al. The South African Medical Journal (2018) CC

BACKGROUND. Asthma is a heterogeneous condition characterised by chronic inflammation and variable expiratory airflow limitation, as well as airway reversibility. The burden of asthma in children is increasing in low- and middle-income countries and remains under-recognised and poorly managed. OBJE... more

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Prioritization of treatments for lower extremity peripheral artery disease in low- and middle-income countries

Fowkes, G.F.; Forster, R.B.; Levin, C.E. et al. International Angiology (2017) CC3

INTRODUCTION: Lower extremity peripheral artery disease (PAD) is increasing in prevalence in low- and middle-income countries creating a large health care burden. Clinical management may require substantial resources but little consideration has been given to which treatments are appropriate for les... more

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Paradise Lost: The Neurobiological and Clinical Consequences of Child Abuse and Neglect

Charles B. Nemeroff Neuron Review (2016) CC

This Review summarizes many of the persistent biological alterations associated with childhood maltreatment including changes in neuroendocrine and neurotransmitter systems and pro-inflammatory cytokines in addition to specific alterations in brain areas associated with mood regulation. Finally, I d... more

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East Japan Earthquake and Tsunami Disaster: Three-Year Report — Building Resilient Communities with Children

Japan Committee for UNICEF (JCU) UNICEF (2014)

The Japan Committee for UNICEF (JCU) has for years endeavored to disseminate important information about children in developing countries and UNICEF’s various assistance programmes there, as well as to fundraise to support those programmes. Unprecedented damage caused by the East Japan Earthquake,... more

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KidsHealth / for Parents / Posttraumatic Stress Disorder (PTSD) (Web-page info sheet)

Shirin Hasan KidsHealth (2018) C2

Webpage providing information about Posttraumatic Stress Disorder (PTSD) for parents

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COVID-19: Sintomas de affecciones respiratorias

Ministerio de Salud Pública de Ecuador (2020) CC

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POST TRAUMATIC STRESS DISORDER (PTSD) - Brochure

The South African Depression and Anxiety Group (SADAG) (2014) C2

Brochure on PTSD: If you are like many South Africans and have been the victim of violent crime, abuse, accidents, loss, or illness, you may be suffering from a very real illness – Post Traumatic Stress Disorder or PTSD. Many victims of trauma in South Africa don’t get help because they feel emb... more

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Post-Traumatic Disorder: Treatment and Referral Guide

The South African Depression and Anxiety Group (2006) C2

How to recognise Post-Traumatic Stress Disorder | The nature and cause of Post-Traumatic Stress Disorder | Treatment and referral | Sources of further information | Compiled by the Scientific & Advisory Board Members of the South African Depression & Anxiety Group, and reviewed by the MRC Research U... more

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Atherosclerosis

British Heart Foundation (2022) CC

Atherosclerosis is the build-up of fatty material (atheroma) inside your arteries. It's a potentially serious condition that causes most heart attacks and strokes but often goes unnoticed.

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Use of Art Therapy in Treating Children With PTSD

Kelly Puent Winona State University (2016) C1

A Capstone Project submitted in partial fulfillment of the requirements for the Master of Science Degree in Counselor Education at Winona State University | This article reviews the use of Art Therapy to treat children who suffer from Posttraumatic Stress Disorder. It explores the clinical need for ... more

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Understand Type 1 Diabetes - Don't ignore the warning signs

Diabetes.co.uk. the global diabetes community (2024) CC2

Poster regarding warnig signs on Diabetes type 1

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Cardiovascular heart disease

British Heart Foundation (2019) CC

Cardiovascular disease (CVD), also called heart and circulatory disease, is an umbrella name for conditions that affect your heart or circulation. These include high blood pressure, stroke and vascular dementia.

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Understanding PTSD Treatment (Guide)

National Center for PTSD U.S. Department of Veterans Affairs (2011) C2

This guide covers: Treatment That Works; Myths About Treatment; Success Stories; Resources | Do you or a loved one have PTSD? There is no need to suffer. Treatment works. If you have PTSD—posttraumatic stress disorder — you don’t have to suffer. There are good treatments that can help. This b... more

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Coronary heart disease

British Heart Foundation (2019) CC

Coronary heart disease (CHD) is when your coronary arteries become narrowed by a build-up of fatty material within their walls. These arteries supply your heart muscle with oxygen-rich blood. CHD is sometimes called ischaemic heart disease.

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Monkeypox Practice Essentials

Graham,M.B. Medscape (2022) CC

Updated August 2022

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WHO: Hypertension

World Health Organization WHO (2023) C_WHO

Key facts - An estimated 1.28 billion adults aged 30–79 years worldwide have hypertension, most (two-thirds) living in low- and middle-income countries - An estimated 46% of adults with hypertension are unaware that they have the condition. - Less than half of adults (42%) with hypertension are... more

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National Guidelines for the Management of Cardiovascular Diseases

Ministry of Health Ghana Republic of Ghana (2019) CC

Cardiovascular diseases (CVDs) are a growing public health problem in Ghana and other African countries. Strokes and other CVDs have become a leading cause of death due to increasing risk factors such as hypertension. According to the Global Burden of Disease study (GBD), ischaemic heart disease was... more

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Nepal: Health Advisory - Seasonal Influenza A (H1N1)

WHO Country Office for Nepal; WHO Health Emergencies Programme in association with UN Clinic, Kathmandu (2017) C_WHO

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Covid-19 AMBOSS. English

AMBOSS (2020) CC

The outbreak of the coronavirus is leading to increased challenges in clinical management and uncertainty among the general population. To support the advice and treatment of patients, we have updated our Knowledge Library to include an informative Learning Card about COVID-19. This update contai... more