This technical report summarizes the discussions on the status of programmatic transition to tenofovir, lamivudine and dolutegravir (TLD) in low– and middle- income countries, addressing the best practices and major challenges faced by HIV programmes.
The latest data on safety and efficacy of do...lutegravir (DTG) containing regimens were also reviewed. The document identified the remaining gaps in knowledge, research, monitoring, and surveillance on DTG and TLD transition and listed the future priorities.
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The World Health Organization (WHO) African Region website provides comprehensive information on cholera outbreaks across the continent. In 2024, 14 countries, including the Democratic Republic of the Congo, Ethiopia, and Nigeria, experienced significant outbreaks, with these three nations categoriz...ed as being in acute crisis.
The site offers access to Monthly Regional Cholera Bulletins, such as the May 2024 edition, which details the status of outbreaks, affected countries, and response measures.
Additionally, the website emphasizes the importance of coordinated responses to cholera outbreaks, highlighting efforts to enhance surveillance, provide medical supplies, and implement vaccination campaigns in high-risk areas.
Overall, the WHO African Region's cholera page serves as a vital resource for understanding the scope of cholera outbreaks and the ongoing initiatives to control and prevent the disease across the continent.
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Noncommunicable diseases (NCDs) are the principal cause of morbidity, disability and premature mortality in Azerbaijan. The most effective way to reduce the NCD burden is to prevent NCD development, by addressing thebehavioural risk factors underlying NCDs at the population and individual leve...ls: smoking, alcohol use, excessive salt intake, low physical activity, overweight and obesity, and unhealthy diets. In Azerbaijan, a national survey of the prevalence of major NCD risk factors, aligned with the WHO-endorsed STEPwise approach to surveillance (STEPS) methodology, was conducted in 2017.
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The Pandemic Influenza Preparedness (PIP) Framework is a World Health Assembly resolution adopted unanimously by all Member States in 2011. It brings together Member States, industry, other stakeholders and WHO to implement a global approach to pandemic influenza preparedness and response. The Frame...work includes a benefit-sharing mechanism called the Partnership Contribution (PC). The PC is collected as an annual cash contribution from influenza vaccine, diagnostic, and pharmaceutical manufacturers that use the WHO Global Influenza Surveillance and Response System (GISRS). Funds are allocated for: (a) pandemic preparedness capacity building; (b) response activities during the time of an influenza pandemic; and (c) PIP Secretariat for the management and implementation of the Framework.
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Many vaccines and drugs hold the promise of reducing mortality and morbidity among pregnant women and infants living in low- and middle-income countries (LMICs). However, sufficient information on the safety of drugs and vaccines in pregnant women is rarely available at the time of product licensure... or approval. To account for this, active safety surveillance efforts are needed during the post-licensure and post-approval
phase to assess the safety of drugs and vaccines in pregnant women and their offspring. Pregnancy exposure registries (PER) are used to monitor the safety of vaccines and drugs. PERs are observational studies that systematically collect health information on exposure to medical products such as drugs and vaccines during pregnancy. This review demonstrates that a number of resources presently exist in LMICs that perform active safety surveillance in pregnant populations. These results indicate such systems employ a wide variety of approaches, each with their own set of strengths and challenges, as summarized in the final section of the report.
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L’Assemblée mondiale de la Santé, tenue en mai 2015, a adopté un Plan d’action mondial pour combattre la résistance aux antimicrobiens, qui définit 5 objectifs:
mieux faire connaître et comprendre le problème de la résistance aux antimicrobiens grâce à une communication, une éduc...ation et une formation efficaces;
renforcer les connaissances et les bases factuelles par la surveillance et la recherche;
réduire l’incidence des infections par des mesures efficaces d’assainissement, d’hygiène et de prévention des infections;
optimiser l’usage des médicaments antimicrobiens en santé humaine et animale;
dégager les arguments économiques en faveur d’investissements durables qui tiennent compte des besoins de tous les pays et accroître les investissements dans la mise au point de nouveaux médicaments, outils diagnostiques, vaccins et autres interventions.
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Given the circulation of the variant of clade I of mpox virus (MPXV) in the African Region, which is associated in the African Region with sustained transmission and the occurrence of cases in a wider range of age groups, including children, the Pan American Health Organization/World Health Organiza...tion (PAHO/WHO) encourages Member States to remain vigilant to the possibility of introduction of this variant in the Americas, and to continue their surveillance efforts, including genomic sequencing of detected cases, with special emphasis on high-risk groups.
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Diabetes country profiles 2016 - The aim of the diabetes country profiles is to synthesize, in one reference document, the national status of diabetes prevention and control. Each profile includes data on diabetes prevalence and trends; mortality; risk factors; availability of diabetes country plans...; monitoring and surveillance; primary prevention and treatment policies and availability of medicines, basic technologies and procedures.
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La pandémie actuelle de COVID-19 entraîne des difficultés exceptionnelles et sans précédent pour les autorités compétentesa responsables des systèmes nationaux decontrôle de la sécurité sanitaire des alimentsb, qui sont tenues de continuer à assurer des fonct...ions et des activités de routine en se conformant aux règlements nationaux et aux recommandations internationales. Dans de nombreux pays, le personnel employé par les autorités compétentes travaille généralement à domicile car le télétravail est devenu la norme et toutes les réunions en présentiel sont annulées ou sont réorganisées sous forme de téléconférence. Il est difficile de maintenir, sans interruption, les activités de routine telles que l’inspection des entreprises du secteur alimentaire, la certification des exportations, le contrôle des denrées alimentaires importées, le suivi et la surveillance de la sécurité de la chaîne d’approvisionnement alimentaire, l’échantillonnage et l’analyse des aliments, la gestion des incidents alimentaires, les conseils sur la sécurité sanitaire des aliments et la réglementation relative aux denrées alimentaires à l’intention de l’industrie et la communication au grand public sur les questions relatives à la sécurité sanitaire des aliments.
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The WHO Cholera Kits 2020 provide essential medical and logistical supplies for responding to cholera outbreaks. Designed to support the first month of an outbreak, the kits include treatment supplies for 100 patients, laboratory testing materials, investigation tools, and infrastructure components ...for patient care. The six kit types cover central, peripheral, and community-level treatment, along with resources for surveillance and outbreak response. The document also outlines recent modifications, ordering procedures, and recommendations for deployment in high-risk areas.
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The document provides comprehensive guidelines on cholera outbreak management, including prevention, diagnosis, and treatment. It emphasizes rapid response measures, the importance of rehydration therapy (oral and intravenous), and public health interventions such as water sanitation, hygiene promot...ion, and disease surveillance to control the spread of cholera in affected communities. It is designed as a resource for healthcare providers and public health officials.
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The immediate objective of the country visit to Cameroon was to ensure that the country is as operationally ready as possible to effectively and safely detect, investigate and report potential Ebola virus disease cases and to mount an effective response that will prevent a larger outbreak. After te...chnical working group meetings, field visits, a “table-top” exercise and a hospital-based simulation exercises were undertaken.
Key strengths and weaknesses were identified, and the following areas for improvement were proposed to the Ministry of Health: coordination, surveillance, contact tracing, infection prevention and control, rapid response teams, case management, social mobilization, laboratory, points of entry, budget, logistics.
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Effective monitoring, epidemiological assessment and evaluation are necessary to achieve the aim of interrupting LF transmission. This manual is designed to ensure that national elimination programmes have available the best information on methodologies and procedures for monitoring MDA, appropriate...ly assessing when infection has been reduced to levels where transmission is likely no longer sustainable, implementing adequate surveillance after MDA has ceased to determine whether recrudescence has occurred, and preparing for verification of the absence of transmission. The manual provides general guidance to national programmes; relevant background information on technical issues is contained in the annexes. As real-life situations may not correspond to predefined categories, consultation with WHO and experts is recommended in complicated situations.
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The technical note by the Global Task Force on Cholera Control (GTFCC) discusses the use of Oral Cholera Vaccines (OCVs) for international workers and travelers in cholera-affected areas. It reviews the effectiveness of WHO-prequalified vaccines (Dukoral®, Shanchol™, and Euvichol®), emphasizing ...their role in preventing infection and reducing transmission risks.
The document highlights concerns about travelers contracting cholera in endemic regions and potentially spreading the disease upon returning home. While the overall risk is considered low, certain groups, such as humanitarian workers and travelers to high-risk areas like South Asia, face a higher exposure.
Recommendations include vaccination for emergency and relief workers who may come into direct contact with cholera patients or contaminated environments. However, routine vaccination for general travelers is not widely recommended. The note also calls for better surveillance and studies to assess the potential of vaccines in preventing international transmission.
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Meeting Report 27-29 October 2020
The overall goal of the meeting was to discuss recent changes in treatment regimens and diagnostics for drug-resistant TB and to determine how these impact on the definition of XDR-TB, with a view to revising this definition. The pre-existing definition of XDR-TB w...as formulated in 2006 at a meeting of the Global Taskforce on XDR-TB, convened by WHO, and has been in use for clinical and surveillance purposes, since this time.
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Antimicrobial resistance (AMR) is a threat to global health and development and it contributes to millions of deaths worldwide each year. Inappropriate use and overuse of antibiotics are driving an increase in AMR and have a detrimental impact on the effectiveness of these critical medicines. Throug...h the Global Action Plan on AMR, WHO is working to improve the surveillance of antimicrobial resistance and reduce inappropriate antibiotic consumption.
There is a recognized need for high-quality resources to improve antibiotic prescribing globally. To address this need, a pragmatic approach was taken by WHO to develop actionable guidance for empiric antibiotic use.
The WHO AWaRe (Access, Watch, Reserve) antibiotic book provides concise, evidence-based guidance on the choice of antibiotic, dose, route of administration, and duration of treatment for more than 30 of the most common clinical infections in children and adults in both primary health care and hospital settings. The information included in the book supports the recommendations for antibiotics listed on the WHO Model Lists of Essential Medicines and Essential Medicines Children and the WHO AWaRe classification of antibiotics.
The WHO AWaRe antibiotic book is accompanied by summary infographics for each infection for both adults and children that provide a quick-reference guide for health care workers at the point of care.
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The World Health Organization (WHO) has identified mental health as an integral component of the COVID-19 response. Its rapid assessment of service delivery for mental, neurological and substance use (MNS) disorders during the COVID-19 pandemic, on which this report is based, is the first attempt to... measure the impact of the pandemic on such services at a global level. The data were collected through a web-based survey completed by mental health focal points at ministries of health between June and August 2020. The questionnaire covered the existence and funding of mental health and psychosocial support (MHPSS) plans, the presence and composition of MHPSS coordination platforms, the degree of continuation and causes of disruption of different MNS services, the approaches used to overcome these disruptions, and surveillance mechanisms and research on MNS data.
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The World Health Organization's cholera fact sheet provides essential information about cholera, an acute diarrheal infection caused by ingesting food or water contaminated with Vibrio cholerae bacteria. The disease remains a global public health threat, particularly in areas lacking safe water and ...adequate sanitation. While many infected individuals exhibit mild or no symptoms, severe cases can lead to rapid dehydration and death if untreated. Prevention focuses on ensuring access to clean water, proper sanitation, and hygiene practices. Effective treatment primarily involves prompt administration of oral rehydration solutions. The fact sheet also highlights the importance of surveillance, preparedness, and response strategies to control outbreaks.
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In February 2008, WHO launched the Atlas of HAT as a collaborative initiative with the Food and Agriculture Organization of the United Nations (FAO), within the framework of the Programme Against African Trypanosomosis (PAAT). The Atlas database is built by the systematic collection of information a...round every HAT case detected worldwide, actively or passively, in endemic and non-endemic countries, and also on the surveillance activities carried out per village. The data are aggregated by year, by location and by some other parameters. All cases and activities are georeferenced at the village level to within an average accuracy of about 1.4 km. The Atlas contains complete information since the year 2000 from the 25 countries reporting at least one HAT case
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The report "Assessing National Capacity for the Prevention and Control of Noncommunicable Diseases" provides an overview of the capacities of countries in the Eastern Mediterranean Region to address noncommunicable diseases (NCDs) based on a 2019 survey. It evaluates the progress of 22 countries in ...areas such as governance, policy implementation, health infrastructure, data collection, and healthcare resources for NCD prevention. The report highlights achievements and gaps, emphasizing the need for strengthened health systems, surveillance, and cross-sectoral collaboration to meet the WHO's global NCD targets. The findings guide further actions to reduce the burden of NCDs in the region.
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