Most of the global burden of sepsis occurs in low- and middle-income countries (LMICs), but the prevalence and etiology of sepsis in LMICs are not well understood. In particular, the lack of laboratory infrastructure in many LMICs has historically precluded an assessment of the pathogens leading to ...sepsis. A recent systematic review found that data describing antimicrobial resistance were absent for 43% of countries in Africa, and only two countries have national antimicrobial resistance plans. In addition, small studies have identified indiscriminate antibiotic use both in and out of hospital settings in sub-Saharan Africa. The absence of microbiological data and lack of antibiotic stewardship complicate sepsis management and almost certainly worsens outcomes, particularly in low-resource systems. The purpose of this study was to examine the prevalence, etiology, and outcomes of sepsis among a cohort of critically ill patients in a referral hospital of Malawi, with a focus on the prevalence of culture-confirmed bacteremia and urinary tract infections.
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A resource for improving menstraul hygiene around the world.
Comprehensive guidance with examples of good practice, information for colleagues and pupils in class and tips on how to break the taboo
En diciembre de 2019 se identificaron los primeros casos del nuevo coronavirus -COVID-19 a nivel global en Wuhan, China. El 11 de marzo de 2020, la Organización Mundial de la Salud -OMS declaró al COVID-19 como pandemia mundial. Si bien la enfermedad se extendió lentamente a los países de Améri...ca Latina y el Caribe -ALC al principio, desde finales del mes de febrero el número de casos confirmados ha aumentado exponencialmente, acercándonos a 2,0 millones de casos confirmados y 124.667 muertos (al 19 de mayo de 2020).
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Lancet Glob Health 2021; 9: e782–92
Community TB care handbook for community health workers
Globally each year, millions of people suffer illness or lose their lives because the vaccines, medicines and diagnostic tests that they need are either unavailable or unaffordable – and this lack of access to medicine is acute in low- and middle-in-
come countries (LMICs). While the COVID-19 pan...demic laid this inequity bare, it also saw the pharmaceutical industry develop and bring new vaccines and treat- ments to market at unprecedented speed. As the world emerges from the worst
of this crisis, pharmaceutical companies are now at an important juncture, where lessons learned from the pandemic can prove pivotal in finding solutions to bridge long-standing gaps in access to medicine in LMICs.
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The document "Management of Type 2 Diabetes Mellitus" provides comprehensive guidelines for the diagnosis, prevention, and treatment of type 2 diabetes in adults. It emphasizes the importance of individualized glycemic targets, lifestyle interventions like diet and exercise, and the use of medicatio...ns such as metformin, SGLT2 inhibitors, and GLP1 receptor agonists to manage blood sugar levels and reduce long-term complications. The document also discusses the screening and management of comorbidities such as hypertension, hyperlipidemia, and diabetic complications like retinopathy, neuropathy, and nephropathy. It highlights the role of diabetes self-management education and support in improving adherence to treatment and patient outcomes. The guidelines are evidence-based and aim to reduce morbidity and mortality associated with type 2 diabetes.
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A Guide to the Application of the WHO Multimodal Hand HygieneImprovement Strategy and the “My Five Moments for Hand Hygiene”Αpproach
As medidas não farmacêuticas incluem medidas de proteção pessoal, medidas ambientais, medidas de distanciamento social e medidas relacionadas com as viagens. Estas considerações detalham a implementação de medidas de distanciamento social e medidas relacionadas com as viagens (doravante deno...minadas “medidas”) descritas nos documentos de orientação provisórios da OMS Ações críticas de preparação, prontidão e resposta à COVID-19, Respondendo à propagação comunitária da COVID-19, e leva em conta o documento da OMS Medidas não farmacêuticas de saúde pública para mitigar o risco e o impacto da influenza epidêmica e pandêmica. No momento de redação deste documento, os países e territórios da Região das Américas experimentam, de modo geral, o mesmo cenário de transmissão. As considerações que estão sendo oferecidas encontram-se sujeitas a revisão à medida que a pandemia evoluir e houver mais informação disponível.
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This document updates the earlier version published in April 2020. In recent weeks, information on the potential use of chloroquine or hydroxychloroquine for the treatment of people with COVID-19 has been disseminated in academic journals and public media. Although there are now ongoing clinical tri...als testing the efficacy and safety of several medicines for COVID-19, as of the date of this document, there is a lack of quality evidence to demonstrate chloroquine and/or hydroxychloroquine are effective in the treatment of COVID-19. Evidence is recently emerging via small studies with sub-optimal methodologies that are conflicting.
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