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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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A8 e-Therapy using computer and mobile technologies in treatment

Karolina Stasiak & Sally Merry IACAPAP (2015) C2

This publication seeks to describe the best treatments and practices based on the scientific evidence available at the time of writing as evaluated by the authors and may change as a result of new research. Readers need to apply this knowledge to patients in accordance with the guidelines and laws o... more

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Guideline for Preventive Chemotherapy for the Control of Taenia solium Taeniasis

Pan American Health Organisation PAHO (2021) C_WHO

The larval stage of the parasite Taenia solium can encyst in the central nervous system causing neurocysticercosis, which is the main cause of acquired epilepsy in the countries in which the parasite is endemic. Endemic areas are those with the presence (or likely presence) of the full life cycle of... more

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WHO recommendation on umbilical vein injection of oxytocin for the treatment of retained placenta

World Health Organization (2020) C_WHO

The recommendation in this document thus supersedes the previous WHO recommendation for the prevention of PPH as published in the 2012 guideline, WHO recommendations for the prevention and treatment of postpartum haemorrhage.

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Guidelines for Care of Critically Ill Adult Patients with COVID-19 in the Americas. Summary, version 3

Pan American Health Organisation PAHO (2021) C_WHO

This publication provides recommendations for the management of critically ill adult patients with COVID-19 being treated in intensive care units (ICUs) in the Americas. These clinical practice guidelines provide evidence-informed recommendations for identifying markers and mortality risk factors in... more

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Water, Sanitation and Hygiene (WASH) in Schools: Guidelines for Timor-Leste, Vol. 1

República Democrática de Timor-Leste (2016) C1

The development of water, sanitation and hygiene (WASH) in schools guidelines for TimorLeste is a landmark moment in our quest to make every school child-friendly – a place where every child can learn, play and grow with pride and dignity. The overarching goal is to improve health, boost education... more

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International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines
recommended

Campos Vieira Abib, S.de; et al. (2022) CC

ecancer has just published a comprehensive set of guidelines for paediatric cancer surgery, applicable to low and high resource settings across the world. You can read the guidelines online The guidelines have been developed by the International Society of Paediatric Surgical Oncology (IPSO) with... more

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Health Sector Response to Gender Based Violence - Standard Operating Procedures for First Contact Point Health Care Providers - Sri Lanka

Ministry of Health, Nutrition & Indigenous Medicine (2019) CC

The United Nations Population Fund (UNFPA) is the lead UN agency working to further gender equality and women’s empowerment in Sri Lanka. We are pleased to be a part of the joint effort with the Ministry of Health to develop the first ‘Standard Operating Procedures on sexual and gender-based vio... more

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Standard Operating Procedure (SOP) for Prompt Testing of TB-HIV and Rapid Access to Treatment and Care Services

National Center for Tuberculosis and Leprosy Control; National Center for HIVAIDS, Dermatology and STD, Cambodia Ministry of Health (2006) CC

External Link

Hepatitis B (chronic): Diagnosis and management of chronic hepatitis B in children, young people and adults

Aftab Ala, Elizabeth Boxall, Steven Bradley et al. National Clinical Guideline Centre (2013)

Clinical guideline, Methods, Evidence and Recommendations In this guideline the following is covered: information needs of people with chronic hep titis B and their carers; where children, young people and adults with chronic hepatitis B a- should be assessed; assessment of liver disease, includi... more

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Selection of essential medicines for South Africa - an analysis of in-depth interviews with national essential medicines list committee members

Velisha Ann Perumal-Pillay & Fatima Suleman BMC Health Services Research (2017) CC

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Quantitative evaluation of essential medicines lists: the South African case study

Velisha Ann Perumal-Pillay & Fatima Suleman BMC Health Services Research (2016) CC

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Clinical Management of HIV in Children and Adults Malawi
recommended

Ministry of Health Malawi; Dept. of HIV and AIDS (2016) C1

Malawi Integrated Guidelines and Standard Operating Procedures for Providing HIV Services. 3rd edition 2016

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Практический справочник ВОЗ по туберкулезу. Модуль 4. Лечение. Лечение лекарственно-устойчивого туберкулеза

World Health Organization WHO (2021) C_WHO

The consolidated guidelines are complemented by an operational handbook which is designed to assist with implementation of the WHO recommendations by Member States, technical partners and others who are involved in the management of patients with DR-TB. The WHO Operational Handbook on Tuberculosis, ... more

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Κατευθυντήριες oδηγίες του Παγκόσμιου Οργανισμού Υγείας για τη φαρμακευτική αντιμετώπιση του επίμονου πόνου σε παιδιά με διάφορες παθήσεις

World Health Organization (2013)

WHO guidelines on the pharmacological treatment of persisting pain in children with medical illnesses

External Link

MSF الإرشادات السريرية. دليل التشخيص والعلاج
recommended

Médecins sans Frontières (MSF) (2022) C2

Clinical Guidelines. Diagnosis and Treatment Manual.

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Ideal Clinic Frameworks and Manual Version 19 (July 2020) - Framework

National Department of Health South Africa (2020) CC

The Ideal Clinic Realisation and Maintenance (ICRM) programme was initiated by the National Department of Health in July 2013 in order to systematically improve primary health care (PHC) facilities and the quality of care they provide. The Ideal Clinic framework/dashboard sets out the standards for ... more

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Peraturan Menteri Kesehatan Republik Indonesia Nomor 87 Tahun 2014 tentang Pedoman Pengobatan Antiretroviral

Ministry of Health Republic of Indonesia (2014) C1

Regulation of the Minister of Health of the Republic of Indonesia on Guidelines for Antiretroviral Treatment

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Sexual Reproductive Health of Women Living HIV/AIDS

World Health Organization; UNFPA (2006)

Guidelines on care, treatment and support for women living with HIV/AIDS and their children in resource-constrained settings

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S2 k-Leitlinie zur Diagnostik, Prävention und Therapie der Tuberkulose im Kindes - und Jugendalter

Feiterna- Sperling, C., F. Brinkmann, C. Adamzik, et al. Deutschen Gesellschaft für Pädiatrische Infektiologie (DGPI) e.V. (2017) C2

Consensus -based guidelines for diagnosis, prevention and treatment of tuberculosis in children and adolescents

International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines recommended

Clinical Management of HIV in Children and Adults Malawi recommended

MSF الإرشادات السريرية. دليل التشخيص والعلاج recommended

International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines
recommended

Clinical Management of HIV in Children and Adults Malawi
recommended

MSF الإرشادات السريرية. دليل التشخيص والعلاج
recommended