Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are... limited to antibiotics with severe side effects. Here, we show that M. ulcerans is susceptible to the anti-tubercular drug Q203 and related compounds targeting the respiratory cytochrome bc1:aa3. While the cytochrome bc1:aa3 is the primary terminal oxidase in Mycobacterium tuberculosis, the presence of an alternate bd-type terminal oxidase limits the bactericidal and sterilizing potency of Q203 against this bacterium. M. ulcerans strains found in Buruli ulcer patients from Africa and Australia lost all alternate terminal electron acceptors and rely exclusively on the cytochrome bc1:aa3 to respire. As a result, Q203 is bactericidal at low dose against M. ulcerans replicating in vitro and in mice, making the drug a promising candidate for Buruli ulcer treatment.
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Chromoblastomycosis (CBM), represents one of the primary implantation mycoses caused by melanized fungi widely found in nature. It is characterized as a Neglected Tropical Disease (NTD) and mainly affects populations living in poverty with significant morbidity, including stigma and discrimination.
A workshop methodology for children, young people and adults
The “Tree of Life” is a psychosocial support tool based on narrative practices that is designed to help participants accept the hardships of their past and identify the strengths that can help them achieve a better future. It uses th...e different parts of a tree as metaphors to represent the different parts of our lives. The workshop generally takes one day.
Participants draw their own “Tree of Life” in which they get to speak of their ‘roots” (where they come from), their skills and knowledge, their hopes and dreams and the special people in their lives
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Previous pandemics have demonstrated that more people could die from the indirect consequences of an outbreak than from the disease itself. As the fight against the pandemic is pushing millions into poverty and hunger, COVID-19 will likely be no different.
This document presents the results of a survey assessing the WASH readiness of schools in UNHCR-supported refugee camps and refugee settlements. UNHCR and partners are using the results to improve water, sanitation and hygiene (WASH) COVID-19 mitigation measures in schools and design targeted improv...ements to WASH facilities to allow for safe operation of schools.
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This publication provides guidance to governments, civil society organizations (nongovernmental organizations and community-based organizations) and other partners implementing HIV prevention, care and treatment programs with key populations. This guide is designed to assist these programs in the de...velopment of monitoring systems for frontline workers (such as peer outreach workers, staff outreach supervisors and program managers) to understand performance. It includes comprehensive tools and forms that various levels of staff can use to collect and analyze data to manage and improve a program.
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В этом документе изложена стратегия
Европейского региона ВОЗ в области
реагирования на COVID-19 и ликвидации
его последствий на основе актуальной
глобальной страт...гии ВОЗ в сфере борьбы
с COVID-19 на период с февраля по декабрь 2020 г.
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Pharmaceutical profile of DRC
The Basic Needs and Response Analysis Framework and Toolkit (known as the Framework & Toolkit) is part of the ECHO ERC funded project to increase the uptake of multi-purpose cash grants (MPGs) in emergency responses for more efficient and effective humanitarian action. MPGs are a powerful aid modali...ty because of their efficiency and effectiveness. They can be combined with other assistance modalities to maximize the benefit for affected communities.
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PLoSONE 12(9):e0184986.https://doi.org/10.1371/journal.pone.0184986
A Resource Book of Inclusive Practices