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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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Ebola emergency preparedness in EU Member States: Conclusions from peer-review visits to Belgium, Portugal and Romania

ECDC (European Centre for Disease Prevention and Control) (2015) CC2

This report presents the main characteristics of Ebola emergency preparedness in three EU Member States. Findings are organised in five sections: preparedness planning, organisational structures, recourses and capacities, intersectoral and cross-border collaboration, and country-specific findings

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Tanzania: HIV Care and Treatment Plan 2003-2008

The William J. Clinton Foundation Ministry of Health, Tanzania (2003) C1

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Climate-Smart Healthcare : Low-Carbon and Resilience Strategies for the Health Sector

The World Bank Group (2017) CC

Climate change is damaging human health now and is projected to have a greater impact in the future. Low- and middle-income countries are seeing the worst effects as they are most vulnerable to climate shifts and least able to adapt given weak health systems and poor infrastructure. Low-carbon appro... more

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WHO technical consultation on oxygen access scale-up for COVID-19

World Health Organization WHO (2021) C_WHO

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Issue and Policy Intersections for Planetary Health

Panorma Perspectives (2018) C2

For the purposes of this review, we are not setting out what exactly implementing the concept of planetary health at a national level should or could look like. This is a complicated and nuanced aspect of moving the concept of planetary health to action that will be highly dependent on the unique ... more

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Are persons with disabilities included in the effort to leave no-one behind? Mapping disability data in development in Asia and the Pacific

United Nations Population Fund UNFPA (2022) C1

In the region, it is estimated that there are over 650 million persons with disabilities. However, without accurate, timely and disaggregated data, countries are unable to develop effective policies and programmes, monitor the wellbeing of persons with disabilities and evaluate the equity and impact... more

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Health system considerations: when influenza meets COVID-19: preparedness and response measures when COVID-19, influenza and acute respiratory infections coincide in the WHO European Region

World Health Organization WHO, Regional Office of Europe (2020) C_WHO

revised version December 2020

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COVID-19: Vaccines Hesperian

Hesperian (2021) C1

Available in different languages

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Global Biodiversity Outlook 5 - arabic version

Convention on Biological Diversity (2020) C2

Global Biodiversity Outlook (GBO) is the flagship publication of the Convention on Biological Diversity (CBD). It is a periodic report that summarizes the latest data on the status and trends of biodiversity and draws conclusions relevant to the further implementation of the Convention. GBO-5 pro... more

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Global competency and outcomes framework for universal health coverage

World Health Organization WHO (2022) C_WHO

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Technical expert meeting on urban health, June 2021: meeting report

World Health Organization WHO (2022) C_WHO

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Strengthening the collection, analysis and use of health workforce data and information: a handbook

World Health Organisation (WHO) (2023) C_WHO

Access to health workers who are fit for purpose, motivated and protected is a fundamental force of health service delivery and the achievement of universal health coverage and the health and health-related Sustainable Development Goals. Data and knowledge of the distribution, skill mix and future d... more

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Effectiveness of a diabetes program based on digital health on capacity building and quality of care in type 2 diabetes: a pragmatic quasi-experimental study

Moreas Morelli, D.; Rubinstein, F.; Santero, M.; et al. BMC Health Services Research, part of Springer Nature (2023) CC2

Health systems in Latin America face many challenges in controlling the increasing burden of diabetes. Digital health interventions are a promise for the provision of care, especially in developing countries where mobile technology has a high penetration. This study evaluated the effectiveness of th... more

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Global Report on Internal Displacement 2021 (GRID 2021)

Internal Displacement Monitoring Centre IDMC; Norwegian Refugee Council NRC Internal Displacement Monitoring Centre IDMC; Norwegian Refugee Council NRC (2021) C1

Internal displacement at all-time high after unprecedented year of crises The total number of people living in internal displacement reached a record 55 million by the end of 2020. During a year marked by intense storms and persistent conflict, 40.5 million new displacements were triggered across... more

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IOM Somalia Preparedness and Response Plan - COVID-19

OCHA; Reliefweb; IOM UN Migration IOM Somalia OCHA; Reliefweb; IOM UN Migration IOM Somalia (2020) C2

April 2020

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Leveraging the Learning Insights from HIV Programming for Pregnant and Parenting Adolescent Girls

UN Children's Fund UNICEF (2023) CC

Pregnancy and childbirth during adolescence profoundly affects the lives of millions of girls worldwide, and is a leading cause of maternal mortality and morbidity, and infant and child mortality. Every year, an estimated 21 million girls aged 15–19 years old in low- and middle-income countries be... more

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Corticosteroids for COVID-19

World Health Organization WHO (2020) C_WHO

WHO published guidance for clinicians and health care decision-makers on the use of corticosteroids in patients with COVID-19. We recommend systemic corticosteroids for the treatment of patients with severe and critical COVID-19. We suggest not to use corticosteroids in the treatment of patients ... more

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Liberia: How reinforced community health structures and capitalizing on lessons learned from the Ebola virus epidemic of 2014–16 helped the country respond to the challenge of its second major disease

World Health Organization WHO (2021) C_WHO

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Towards a pastoral care in Africa

Brundson, A.F. (2020) CC

Chapter in: Reformed theology today: Practical-theological, missiological and ethical perspectives