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Respite care for carers of people with dementia

World Health Organization (2012) C_WHO
Q10: For carers of people with dementia, does respite care when compared to care as usual, produce benefits/harm in the specified outcomes?
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Interventions for carers of people with dementia

World Health Organization (2012) C_WHO
Q9: For carers of people with dementia, do interventions (psychoeducational, cognitive-behavioural therapy counseling/case management, general support, training of caregivers, multi-component interventions and miscellaneous interventions) when compared to placebo/comparator, produce benefits/harm in ... more
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Role of antidepressants in people with dementia and associated depression

World Health Organization (2012) C_WHO
Q4: For people with dementia with associated depression, do antidepressants when compared to placebo/comparator produce benefits/harm in the specified outcomes?
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Role of Memantine

World Health Organization (2012) C_WHO
Q2: For people with dementia, does memantine, when compared to placebo/comparator, produce benefits/harm in the specified outcomes in non-specialist health settings?
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Cognitive and psychosocial interventions

World Health Organization (2012) C_WHO
Q5: For people with dementia, which cognitive/psychosocial interventions (such as cognitive stimulation, cognitive rehabilitation, reality orientation, reminiscence therapy) when compared to placebo/comparator produce benefits/harm in the specified outcomes?
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Diagnosis of dementia

World Health Organization (2012) C_WHO
Q6: Can dementia be diagnosed at first or second level care by non-specialist health care providers? What should be the assessment process for the diagnosis of dementia?
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How to deliver the diagnosis of dementia

World Health Organizationl (2012) C_WHO
Q7: For people with dementia, who should be told of the diagnosis and how should the diagnosis be delivered?
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Dementia in low-income and middle-income countries: Different realities mandate tailored solutions

Ferri; C.P.; and K. S. Jacob PLOS Medicine (2017) CC
Published: March 28, 2017https://doi.org/10.1371/journal.pmed.1002271 PLoS Med 14(3): e1002271. https://doi.org/10.1371/journal.pmed.1002271
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Psychological interventions in adults and children with epilepsy

World Health Organization WHO (2012) C_WHO
Q 10: In adults and children with epilepsy, which psychological interventions used as adjunctive therapies with antiepileptic drugs when compared to placebo/comparator produce benefits/harm in specified outcomes?
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When to discontinue antiepileptic drug treatment in adults and children

World Health Organization WHO (2012) C_WHO
Q9. In adults and children with convulsive epilepsy in remission, when should treatment be discontinued?
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Role of neuroimaging in management of convulsive epilepsy

World Health Organization WHO (2012) C_WHO
Q6: What is the added advantage of doing neuroimaging in people with convulsive epilepsy in non-specialist settings in low and middle income countries?
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EPI 4: Antiepileptic medications for adults and children with HIV

World Health Organization WHO (2015) C_WHO
Scoping Question: For adults and children living with HIV, which antiepileptic medications (such as phenobarbital, phenytoin, carbamazepine or valproic acid) produce benefits and/or harms when compared to a placebo or controls?
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Role of EEG in management of convulsive epilepsy

World Health Organization WHO (2012) C_WHO
Q5: What is the added advantage of doing an electroencephalography (EEG) in people with convulsive epilepsy in non- specialist settings in low and middle income countries?
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Standard antiepileptic drugs (phenobarbital, phenytoin, carbamazepine, valproic acid) for management of convulsive epilepsy in adults and children

World Health Organization (2012) C_WHO
Q 7: For adults and children with convulsive epilepsy, which standard antiepileptic drugs (phenobarbital, phenytoin, carbamazepine, valproic acid) when compared to placebo/a comparator produce benefits/harm in the specified outcomes?
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EPI 2: First-line anti-epileptic medication for management of acute convulsive seizures, when intravenous access is available [2015]

mhGAP; WHO (2015) C_WHO
SCOPING QUESTION: In adults with acute convulsive seizures, where intravenous access is available, which first-line anti- epileptic medication should be used to abort seizures when compared to comparator?
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EPI 1: Antiepileptic medications for management of acute convulsive seizures when no intravenous access is available

World Health Organization WHO (2015) C_WHO
[Updated 2015] Scoping Question: In adults with acute convulsive seizures in first-level care or in the community (when no IV access is available), which antiepileptic medications produce benefits and/or harm when compared to comparator?
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EPI 5: Anti-epileptic medicines for medication resistant convulsive epilepsy. [New 2015]

mhGAP; WHO (2015) C_WHO
SCOPING QUESTION: For adults and children with medication-resistant convulsive epilepsy, which anti-epileptic medications produce benefits and/or harm in the specified outcomes when compared to a placebo or a comparator?
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EPI 3: Anti-epileptic medications for management of established status epilepticus [Updated 2015]

mhGAP; WHO (2015) C_WHO
SCOPING QUESTION: In adults with established status epilepticus (i.e., seizures persisting after the first-line treatment with benzodiazepines [or benzodiazepines-resistant status epilepticus]), which anti-epileptic medications are associated with cessation of seizures and reduced adverse effects)? ... more
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Antiepileptic drug therapy in individuals with intellectual disability & epilepsy

World Health Organization (2012) C_WHO
Q12: Should the treatment be similar in individuals with intellectual disability and epilepsy compared to people with epilepsy only?
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Management of epilepsy in women of child bearing age

World Health Organization (2012) C_WHO
Q11: 11a). In women with epilepsy, should antiepileptic therapy be prescribed as monotherapy or polytherapy to decrease the risk of fetal malformations? 11b). Does the use of folic acid preconceptually decrease the risk of foetal malformations in women with epilepsy? 11c). Do phenytoin, phenobarbi ... more