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Toolboxes
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2
The burden of severe asthma in sub-Saharan Africa: Findings from the African Severe Asthma Project
Kirenga, B.J.; Chakaya, J.; Yimer, G. et al.
Journal of Allergy and Clinical Immunology: Global
(2024)
CC
Severe asthma is associated with high morbidity, mortality, and health care utilization, but its burden in Africa is unknown. This article wants to determine the burden (prevalence,
mortality, and activity and work impairment) of severe asthma in 3
...
countries in East Africa: Uganda, Kenya, and Ethiopia using the American Thoracic Society/European Respiratory Society case definition of severe asthma.
more
Module 2.1
At the end of this course, you should be able to:
- draft an airport public health contingency plan for managing COVID-19 cases and outbreaks in aviation;
- manage an outbreak of COVID-19
...
disease in aviation.
Target audience:
- National IHR Focal Points (NFPs)
- Airport health authorities and local, provincial, and national health surveillance and response systems
- Civil aviation authorities, airport operators, aircraft operators, airports, and airlines
more
Six months since the start of Congo’s latest Ebola outbreak – the second worst in history, with more than 400 people dead – this special report evaluates efforts to prevent the disease from sp
...
reading internationally and sparking a regional crisis
more
This guideline provides evidence-informed guidance on the use of non-sugar sweeteners to reduce the risk of unhealthy weight gain and diet-related noncommunicable diseases in adults and children. T
...
he guidance in this guideline is not based on toxicological assessments of the safety of individual non-sugar sweeteners and is therefore not intended to update or replace guidance on safe or maximal levels of intake established by the Joint Food and Agriculture Organization of the United Nations (FAO)/WHO Expert Committee on Food Additives (JECFA) or other authoritative bodies.
more
Burden of fungal asthma in Africa: A systematic review and meta-analysis
Kwizera, R.; Musaazi, J.; Meya, D.B.; et al.
PLOS ONE, which is part of the Public Library of Science (PLOS)
(2019)
CC2
Asthma is one of the neglected diseases in Africa with a high prevalence. Allergic fungal diseases have been reported to complicate asthma progression and treatment outcomes. However, data about fungal asthma and its associated complications are lim
...
ited in Africa. We aimed to estimate the burden of fungal asthma among adults and children in Africa using a systematic review.
more
Obesity and diabetes are affecting the peoples of the Americas at high and increasing rates. National surveys demonstrate that obesity is increasing in prevalence among all age groups; 7% to 12% of
...
children under 5 years old and
one-fi fth of adolescents are obese, while rates of overweight and obesity among adults approach 60%. Obesity is the major modifi able risk factor for diabetes.
more
Asthma is the most common chronic condition in children worldwide. It affects daytime activities, sleep and school attendance and causes anxiety to parents, families and other carers. The quality of asthma diagnosis and management globally still nee
...
ds substantial improvement. From infancy to the teenage years, there are age-specific challenges, including both underdiagnosis and overdiagnosis with stigma-related barriers to treatment in some cultures and in adolescents. The Paediatric Asthma Project Plan has been initiated to strengthen diagnosis and management of asthma. This encompasses a vision for the next 10–15 years, building on the knowledge and experience from previous educational projects. It will take into account the educational needs of patients, carers and healthcare professionals as well as the accessibility and affordability of medication, particularly in low and middle-income countries where the prevalence of asthma is rising more rapidly. This overview presents a first step for those involved in the diagnosis and management of childhood asthma to strengthen care for children globally.
more
The document "Management of Type 2 Diabetes Mellitus" provides comprehensive guidelines for the diagnosis, prevention, and treatment of type 2 diabetes in adults. It emphasizes the importance
...
of individualized glycemic targets, lifestyle interventions like diet and exercise, and the use of medications such as metformin, SGLT2 inhibitors, and GLP1 receptor agonists to manage blood sugar levels and reduce long-term complications. The document also discusses the screening and management of comorbidities such as hypertension, hyperlipidemia, and diabetic complications like retinopathy, neuropathy, and nephropathy. It highlights the role of diabetes self-management education and support in improving adherence to treatment and patient outcomes. The guidelines are evidence-based and aim to reduce morbidity and mortality associated with type 2 diabetes.
more
J Fungi (Basel) . 2019 Aug 16;5(3):75. doi: 10.3390/jof5030075 . Namibia is a sub-Saharan country with one of the highest HIV infection rates in the world. Although care and support services are available that cater for opportunistic infections rela
...
ted to HIV, the main focus is narrow and predominantly aimed at tuberculosis. We aimed to estimate the burden of serious fungal infections in Namibia, currently unknown, based on the size of the population at risk and available epidemiological data. Data were obtained from the World Health Organization (WHO), Joint United Nations Programme on HIV/AIDS (UNAIDS), and published reports.
more
The World Health Organization (WHO) Global Diabetes Compact (GDC) was created as a global initiative to improve diabetes prevention and care, and to contribute to the global targets to reduce premature mortality due to noncommunicable diseases by one-third by 2030.
Compendium of WHO and other UN guidance on health and environment - 2022 update
World Health Organization WHO
World Health Organization WHO; UN environment programme; UNDP; unicef
(2022)
C_WHO
The combined effects from ambient (outdoor) air pollution and indoor (household, in particular) air pollution cause approximately 7 million premature deaths every year, largely as a result of increased mortality from stroke, IHD, COPD, lung cancer a
...
nd acute respiratory infections (1). Air pollution can occur in both the outdoor and indoor environments. Cook-stoves in homes, motor vehicles, industrial facilities and forest fires are common sources of air pollution. Air pollutants with the strongest evidence for adverse health outcomes include particulate matter (PM; both PM 2.5 (i.e. particles with an aerodynamic diameter
equal to or less than 2.5 μm) and PM10 (i.e. particles with an aerodynamic diameter equal to or less than 10 μm), ozone (O 3), nitrogen dioxide (NO 2 ), sulfur dioxide (SO 2 ) and carbon monoxide (CO). Air pollution is however composed of many more pollutants (1).
more
Most of the global burden of sepsis occurs in low- and middle-income countries (LMICs), but the prevalence and etiology of sepsis in LMICs are not
...
well understood. In particular, the lack of laboratory infrastructure in many LMICs has historically precluded an assessment of the pathogens leading to sepsis. A recent systematic review found that data describing antimicrobial resistance were absent for 43% of countries in Africa, and only two countries have national antimicrobial resistance plans. In addition, small studies have identified indiscriminate antibiotic use both in and out of hospital settings in sub-Saharan Africa. The absence of microbiological data and lack of antibiotic stewardship complicate sepsis management and almost certainly worsens outcomes, particularly in low-resource systems. The purpose of this study was to examine the prevalence, etiology, and outcomes of sepsis among a cohort of critically ill patients in a referral hospital of Malawi, with a focus on the prevalence of culture-confirmed bacteremia and urinary tract infections.
more
The overall objective of this approach is to accelerate efforts toward malaria elimination by increasing
access to early diagnosis and treatment. The specific objectives are to: Minimize the barriers that the population faces in accessing timely, q
...
uality diagnosis and treatment. Reduce the time between diagnosis and the start of treatment. Reduce the parasite reservoir in symptomatic infected persons through early treatment. Maximize the transmission-blocking strategy by taking early action on gametocytes. Decrease the incidence of P. vivax relapses.Ultimately, disrupt malaria transmission and prevent mortalit.
more
There are 3 main forms of leishmaniases: visceral (the most serious form because it is almost always fatal without treatment), cutaneous (the most common, usually causing skin ulcers), and mucocutaneous (affecting mouth, nose and throat).
Leishmani
...
asis is caused by protozoan parasites which are transmitted by the bite of infected female phlebotomine sandflies.
The disease affects some of the world’s poorest people and is associated with malnutrition, population displacement, poor housing, a weak immune system and lack of financial resources.
An estimated 700 000 to 1 million new cases occur annually.
Only a small fraction of those infected by parasites causing leishmaniasis will eventually develop the disease.
more
Background: The impacts of air pollutants on health range from short-term health impairments to hospital admissions
and deaths. Climate change is leading to an increase in air pollution.
Issue Brief: Ebola
recommended
MEDBOX Issue Brief no. 24 (Sept.2022)
On 20 September 2022, Uganda health authorities declared an outbreak of Ebola disease, caused by Sudan virus,
following laboratory confirmation
...
of a patient from a village in Madudu sub-county, Mubende district, central
Uganda.
Therefore the MEDBOX Team created this issue brief to give a quick overview of the most important documents and training material.
more
The document provides detailed clinical guidelines for the therapy of Type 1 Diabetes as developed by the German Diabetes Association (DDG). It focuses on individualized insulin therapy, structured patient training, and monitoring
...
of blood glucose levels. The guidelines emphasize preventing complications like ketoacidosis and hypoglycemia while improving patients' quality of life through education and tailored medical care. Recommendations include the use of both basal and bolus insulin, continuous glucose monitoring, and integrating psychosocial support into treatment plans. The document serves as a comprehensive resource for healthcare professionals managing Type 1 Diabetes.
more
Emergency WASH in Health Facilities in Conflict Affected Locations 756 health workers trained on disease surveillance and outbreak response.
Around 142 health workers trained on integrated health (WASH and Nutrition) response. 405 health facilities
...
are equipped with functional incinerators.
Quality Essential Clinical Health Services 194 health workers are trained on clinical management of rape (CMR) in 2018. 259 sexual and gender based violence (SGBV) survivors referred to the health facilities.
Improving Resilience- Mental Health Response 514 health workers trained on mental health and psychosocial support (MPHSS) in conflict affected areas.
more
Multi-country outbreak of cholera External Situation Report # 23, published 20 February 2025
