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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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WHO consolidated guideline on self-care interventions for health: sexual and reproductive health and rights

World Health Organization WHO (2019) C_WHO

Self-care interventions are among the most promising and exciting new approaches to improve health and well-being, both from a health systems perspective and for people who use these interventions. The World Health Organization (WHO) uses the following working definition of self-care: Self-care is t... more

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Achieving Control of Asthma in Children in Africa (ACACIA): protocol of an observational study of children’s lung health in six sub-Saharan African countries

Mosler, G.; Oyenuga, V.; Addo-Yobo, E. et al. BMJ Open (2020) CC

Little is known about asthma control in the rising number of African children who suffer from this condition. The Achieving Control of Asthma in Children in Africa (ACACIA) study is an observational study collecting evidence about paediatric asthma in urban areas of Ghana, Malawi, Nigeria, South Afr... more

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Strategic Framework for Enhancing Prevention and Control of mpox, 2024-2027

World Health Organization WHO (2024) C_WHO

Mpox continues to affect people around the world. A new framework released today by WHO will guide health authorities, communities and other stakeholders in preventing and controlling mpox outbreaks, eliminating human-to-human transmission of the disease, and reducing spillover of the virus from ani... more

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Fever Diagnostic Technology Landscape
recommended

UNITAID World Health Organisation (WHO) (2018) C_WHO

1st edition. Unitaid’s report describes a slate of new devices that can more efficiently identify dangerously ill children so that they can be treated immediately. These tools make it easier to recognize danger signs, and support integrated approaches to reducing childhood deaths from the three ... more

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The WHO AWaRe (Access, Watch, Reserve) antibiotic book - Infographics

World Health Organisation (WHO) (2022) C_WHO

Antimicrobial resistance (AMR) is a threat to global health and development and it contributes to millions of deaths worldwide each year. Inappropriate use and overuse of antibiotics are driving an increase in AMR and have a detrimental impact on the effectiveness of these critical medicines. Throug... more

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Population and Individual Approaches to the Prevention and Management of Diabetes and Obesity

Pan American Health Organization PAHO (2011) C_WHO

Obesity and diabetes are affecting the peoples of the Americas at high and increasing rates. National surveys demonstrate that obesity is increasing in prevalence among all age groups; 7% to 12% of children under 5 years old and one-fi fth of adolescents are obese, while rates of overweight and obe... more

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Major storm on the horizon: Health and macroeconomic burdens of noncommunicable diseases and mental health conditions in South America
New

Pan American Health Organization PAHO (2025) C_WHO

Noncommunicable diseases (NCDs) (e.g., cardiovascular diseases, cancers, diabetes, and chronic respiratory diseases) and mental health conditions (e.g., Alzheimer’s disease and related dementias, depression, anxiety, autism spectrum disorders) are the world’s leading cause of preventable illness... more

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Safe Back to School: A Practitioner’s Guide

Save the Children; Education Cluster; Protection Cluster et al. (2020) C2

The global COVID-19 pandemic has led to unprecedented levels of disruption to education, impacting over 90% of the world’s student population: 1.54 billion children, including 743 million girls. School closures and the wider socio-economic impacts of COVID-19 on communities and society also disrup... more

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Diagnóstico rápido: Situación de los migrantes venezolanos con VIH en el Perú

ONUSIDA (2019) C1

Thousands of HIV-positive Venezuelans have been forced to leave the country, after facing discrimination and zero treatment options, according to UNAIDS. Patients once received free ARV treatment under Venezuela’s National AIDS Program. In 2017, the country essentially ran out of ARVs—about 9 p... more

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Remote Psychological First Aid during COVID-19 – May 2020

IFRC Reference Centre for Psychosocial Support IFRC Reference Centre for Psychosocial Support (2020) CC

Psychological first aid (PFA) is a method of helping people in distress so they feel calm and supported to cope better with their challenges. It is a way of assisting someone to manage their situation and make informed decisions. The basis of psychological first aid is caring about the person in dis... more

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An integrated, Sustainable Framework to Elimination of Communicable Diseases in the Americas. Concept Note

Pan American Health Organisation (PAHO) (2019) C_WHO

The objective of this concept note and the framework it outlines is the elimination of a group of CDs and the negative health effects they generate, which together create a tangible burden on affected individuals, their families and communities, and on health care systems throughout the Region. Thou... more

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Pediatric oncology nursing practice in Latin America and the Caribbean

Pan American Health Organisation PAHO (2024) C_WHO

One of the main aims of the WHO Global Initiative for Childhood Cancer and the CureAll Americas framework is to strengthen centers of excellence and promote the training of the health workforce, especially pediatric oncology nurses, specialized in nursing care for children and adolescents with cance... more

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WHO Model Formulary
recommended

World Health Organization WHO (2008) C_WHO

For each medicine the Formulary provides information on use, dosage, adverse effects, contraindications and warnings, supplemented by guidance on selecting the right medicine for a range of conditions

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Lesotho: NATIONAL GUIDELINES ON THE USE OF ANTIRETROVIRAL THERAPY FOR HIV PREVENTION AND TREATMENT

Ministry of Health, Government of Lesotho (2016) C2

National Guidelines for HIV & AIDS Care and Treatment (5th Edition)

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Epilepsy

World Health Organization (2004) C_WHO

Brief review of selected topics The following pages provide a focus on selected areas in relation to neurology. The specialists who contributed the reviews are listed in the Project Team and Partners Neurology Atlas (2004)

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Child marriage (Age 16-24)

PATA; READ (Resilient & Empowered Adolescents & Young People) (2019) C2

Accessed: 30.10.2019

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Cambodia Demographic and Health Survey 2010

National Institute of Statistics, Directorate General for Health, and ICF Macro (2011) C1

External Link

South Africa Demographic and Health Survey 2016

National Department of Health - NDoH, Statistics South Africa, South African Medical Research Council SAMRC, and ICF (2019) CC

Large File: 12 MB!

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Cambodia Demographic and Health Survey 2014

National Institute of Statistics, Directorate General for Health, and ICF International (2015) C1

Fever Diagnostic Technology Landscape recommended

Major storm on the horizon: Health and macroeconomic burdens of noncommunicable diseases and mental health conditions in South America New

WHO Model Formulary recommended

Fever Diagnostic Technology Landscape
recommended

Major storm on the horizon: Health and macroeconomic burdens of noncommunicable diseases and mental health conditions in South America
New

WHO Model Formulary
recommended