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Guidelines
HIV testing services
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Compendium of Case Studies
Cryptococcal disease is one of the most common opportunistic infections among people living with advanced HIV disease and is a major contributor to severe illness, morbidity, and mortality, particularly in sub-Saharan Africa.
These guidelines update the recommendations that were first released i...n 2018 on diagnosing, preventing, and managing cryptococcal disease. In response to important new evidence that became available in 2021, these new guidelines strongly recommend a single high dose of liposomal amphotericin B as part of the preferred induction regimen for the treatment of cryptococcal meningitis in people living with HIV. This simplified regimen - a single high dose of liposomal amphotericin B paired with other standard medicines (flucytosine and fluconazole) - is as effective as the previous WHO standard of care, with the benefits of lower toxicity and fewer monitoring demands.
The objective of these guidelines is to provide updated, evidence-informed recommendations for treating adults, adolescents and children living with HIV who have cryptococcal disease. These guidelines are aimed at HIV programme managers, policymakers, national treatment advisory boards, implementing partners and health-care professionals providing care for people living with HIV in resource-limited settings with a high burden of cryptococcal disease.
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New generations free of HIV, syphilis, hepatitis B and Chagas disease in the Americas 2018
M. Alonso González; M. B. Mello; L. Sereno; et al.
Pan American Health Organization; World Health Organization (Americas); Unicef
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J Acquir Immune Defic Syndr; Wolters Kluwer Health
(2017)
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J Acquir Immune Defic Syndr Volume 75, Supplement 2, June 1, 2017 www.jaids.com
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