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1
Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents With HIV
recommended
Panel on Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents With HIV
ClinicalInfo.gov
(2025)
C_CDC
The Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and
Adolescents With HIV document is published in an electronic format and updated as relevant changes
in prevention and treatment recommendations occur.
Tuberculosis (TB) remains a serious public health threat in South Africa and is the
leading cause of death in people living with HIV (PWH). Pre-hospital and early in-
hospital mortality is of particular concern in PWH. Significant progress has been made
to date, but a monumental effort is require
...
d to reach the END TB target of zero deaths
due to TB by 2035. One of the measures would be to curb early in-hospital mortality
due to TB. This goal provided impetus for the development of this package of care.
more
Core Guidance. Differentiated service delivery is highlighted as a key approach for HIV programmes to enhance implementation quality and efficiency.
Prevention of mother-to-child HIV transmission (PMTCT) has been a success in many respects
but there is still much to do to eliminate mother-to child transmission (MTCT), particularly in low
antiretroviral therapy (ART) coverage areas and in the postnatal phase. The success of PMTCT is
highly dep
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endent on the availability and accessibility of patient-centred care, which enables women
and their families to take informed decisions about their health and the health of their infant. For
this reason, it is recommended to have a patient-centred approach when implementing PMTCT.
PMTCT success is also linked to the partners’ involvement, as well as to community acceptance
of HIV.
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What works?
Bhana A et al. Journal of the International AIDS Society 2021, 24(S2):e25713
Journal of Adolescent Health 2022 1-16
This comprehensive analysis outlines the recommended mental health services in HIV
care, delivery modalities, required resources, guideline integration, special population
considerations, and implementation strategies with real-world examples
This training seeks to equip health workers who have contact with children in HIV settings with the knowledge and skills to better integrate violence against children (VAC) services into their work. It seeks to transmit information and skills to make them: feel comfortable talking with, providing se
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rvices and making appropriate referrals to children and their caregivers who are at risk of or experiencing violence.
This three-day training package includes ten modules to be delivered to groups of 25-30 health workers. The training is aimed at different cadres of health workers, including: nurses and midwives; clinicians; HIV counselors; medical social workers; pharmacists; community health workers, and others who are involved in children’s health care in health settings
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This technical brief describes promising models that demonstrate how FBOs could contribute to expanded access to improved HIV and other services for men. These models incorporate a range of WHO-recommended interventions and highlights operational considerations and key success factors. By capitalizi
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ng on their strengths, FBOs can potentially serve as useful platforms for engaging men and other priority populations, promoting greater demand, uptake, and retention in care.
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Advanced Clinical Care (ACC) Live Tutorial session 22 August 2024
The paper “Artificial Intelligence for Public Health Surveillance in Africa: Applications and Opportunities” examines how artificial intelligence (AI) can improve public health systems across Africa, particularly in low-resource settings. It explores how machine learning and other AI techniques
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are being used for disease detection, outbreak prediction, real-time surveillance, and health resource management.
The authors focus on major public health challenges such as HIV, cholera, Ebola, measles, tuberculosis, malaria, COVID-19, and mental health. Through numerous case studies, the paper shows that AI can enhance the accuracy and speed of disease detection, predict outbreaks more effectively than traditional methods, support vaccination strategies, and optimize healthcare resource allocation. At the same time, it discusses important barriers to implementation, including limited data quality, infrastructure constraints, ethical concerns, and shortages of technical expertise.
Overall, the paper highlights AI’s strong potential to strengthen disease surveillance and health outcomes in Africa while emphasizing the need for careful integration, improved data systems, and supportive policy frameworks.
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The document “Strategic Framework for Strengthening Cross-Border Surveillance and Information Sharing in Africa” outlines a coordinated strategy developed by Africa CDC to improve public health surveillance and collaboration across national borders in Africa. It addresses the challenge that infe
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ctious diseases often spread across borders due to population movement, trade, and migration, while surveillance systems and data-sharing mechanisms frequently remain nationally focused and fragmented.
The framework proposes strengthening regional coordination, harmonizing surveillance systems, enhancing information sharing between countries, and building laboratory and workforce capacity. It also emphasizes timely detection of cross-border health threats, joint outbreak investigations, and improved communication among Member States. Overall, the document aims to enhance preparedness, early warning systems, and collective response to public health threats across the African continent.
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O documento intitulado “Fortalecimento da Vigilância Transfronteiriça e do Compartilhamento de Informações na África” apresenta uma estratégia coordenada elaborada pelo Africa CDC para melhorar a vigilância em saúde pública e a colaboração além das fronteiras nacionais na Áfric
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a. Ele destaca o desafio de que as doenças infecciosas frequentemente se propagam através das fronteiras devido ao movimento de pessoas, ao comércio e à migração, enquanto os sistemas de vigilância e os mecanismos de compartilhamento de dados permanecem muitas vezes centrados no nível nacional e fragmentados.
O quadro estratégico propõe fortalecer a coordenação regional, harmonizar os sistemas de vigilância, melhorar o intercâmbio de informações entre os países e desenvolver a capacidade dos laboratórios e dos recursos humanos. Também enfatiza a importância da detecção oportuna de ameaças sanitárias transfronteiriças, de investigações conjuntas de surtos e de uma comunicação aprimorada entre os Estados-membros. De modo geral, o documento visa reforçar a preparação, os sistemas de alerta precoce e a resposta coletiva às ameaças à saúde pública no continente africano.
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Despite gains in childhood survival, more effort is needed to improve the well-being of children with developmental delays and disabilities. All children, including children with developmental delays and disabilities, need nurturing care. Nurturing care can contribute to preventing developmental del
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ays and protect children who are exposed to risk factors, as well as improve functioning and long-term outcomes for children with developmental disabilities. This Brief outlines why and how nurturing care is relevant for children with developmental delays and disabilities. Recognizing that these children have diverse needs requiring different levels of coordinated and family-centred support, it recommends a set of actions to strengthen policies, services, communities and caregiver capabilities so that these children receive nurturing care.
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There has been major progress in the HIV response in eastern and southern
Africa, the region most affected by the HIV pandemic.
medRxiv preprint;https://doi.org/10.64898/2026.02.18.26346597. This model application demonstrates that the sudden cessation of USAID and CDC
commitments in the largest HIV epidemic in the world leads to increased incidence and mortality
and threatens decades of progress in KZN, South Africa. Rest
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oring funding within 12 months
and increasing efficiency of HIV interventions can reestablish KwaZulu Natal province, South
Africa’s trajectory toward EHE goals.
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This guide aims to support the implementation of evidence-based practices to reduce morbidity and mortality due to postpartum haemorrhage (PPH). Implementation is a multidisciplinary process that requires engagement from multiple stakeholders. Furthermore, implementation can and should be pursued in
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a systematic and evidence-based manner.
This Implementation guide presents a structured process that will aid countries in their efforts to incorporate the latest PPH recommendations into national PPH guidelines and clinical practice.
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