The cardiovascular disease continuum begins with risk factors such as diabetes mellitus (DM), progresses to vasculopathy and myocardial dysfunction, and finally ends with cardiovascular death. Diabetes is associated with a 2- to 4-fold increased risk for heart failure (HF). Moreover, HF patients wit...h DM have a worse prognosis than those without DM. Diabetes can cause myocardial ischemia via micro- and macrovasculopathy and can directly exert deleterious effects on the myocardium. Hyperglycemia, hyperinsulinemia, and insulin resistance can cause alterations in vascular homeostasis. Then, reduced nitric oxide and increased reactive oxygen species levels favor inflammation leading to atherothrombotic progression and myocardial dysfunction. The classification, diagnosis, and treatment of HF for a patient with and without DM remain the same. Until now, drugs targeting neurohumoral and metabolic pathways improved mortality and morbidity in HF with reduced ejection fraction (HFrEF). Therefore, all HFrEF patients should receive guideline-directed medical therapy. By contrast, drugs modulating neurohumoral activity did not improve survival in HF with preserved ejection fraction (HFpEF) patients. Trials investigating whether sodium-glucose cotransporter-2 inhibitors are effective in HFpEF are on-going. This review will summarize the epidemiology, pathophysiology, and treatment of HF in diabetes.
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Noncommunicable diseases (NCDs) such as cancer, cardiovascular diseases, diabetes and chronic respiratory diseases and their risk factors are an increasing public health and development challenge in Kyrgyzstan. This report provides evidence through three analyses that NCDs reduce economic outp...ut and discusses potential options in response, outlining details of their relative returns on investment. An economic burden analysis shows that economic losses from NCDs are equivalent to 3.9% of gross domestic product. An intervention costing analysis provides an estimate of the funding required to implement a set of policy interventions for prevention and clinical interventions. A cost–benefit analysis compares these implementation costs with the estimated health gains and identifies which policy packages would give the greatest returns on investment.
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Всемирный доклад о наркотиках 2016 года публикуется по завершении знаменательного события в истории глобальной политики в отношении наркотиков – специальной сесс...и Генеральной Ассамблеи по мировой проблеме наркотиков. В главе I представлен общий обзор ситуации с предложением опиатов, кокаина, каннабиса, стимуляторов амфетаминового ряда (САР) и новых психоактивных веществ (НПВ) и спросом на них, а также их воздействия на здоровье человека. В ней рассматриваются также научные данные о полинаркомании, обращаемости за лечением в связи с потреблением каннабиса и изменениях, произошедших после легализации потребления каннабиса в рекреационных целях в некоторых районах мира. Глава II сосредоточена на рассмотрении механизмов взаимодействия мировой проблемы наркотиков и всех аспектов устойчивого развития через призму целей в области устойчивого развития.
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Towards a Healthier Botswana
Esta guía trata de la primera ayuda psicológica, un modo práctico y humano para ayudar y apoyar a nuestros semejantes en graves situaciones de crisis. Se ha pensado para personas que se tienen la posibilidad de ayudar a
otras que han experimentado un hecho extremadamente angustiante. Proporciona... un marco de
trabajo para apoyar a las personas respetando su dignidad, cultura y capacidades. A pesar de su
nombre, la primera ayuda psicológica se ocupa tanto del apoyo social como del psicológico.
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Learning from earthquake relief and recovery operations
Medicina (Kaunas) 2013;49(7):335-40
Guidance
Indicators for monitoring the 2016 Political Declaration on Ending AIDS
UNAIDS Joint United Nations Programme on HIV/AIDS
Urban poor communities including the homeless, residents of informal settlements, residents at risk of being evicted, Internally Displaced Persons (IDPs), undocumented persons, low-income renters, as well as homeowners are perhaps at greatest risk from both COVID-19 and the response interventions to... it.
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UNAIDS/WHO Working Group on Global HIV/AIDS and STI Surveillance
Guiding framework for development cooperation, Working paper 2017.
This document was drawn up on the basis of expert publications and inputs from partners in the
GIZ regional programme Psychosocial Support for Syrian and Iraqi Refugees and Internally
Displaced People1 in order to serve as guidanc...e in the design, implementation and assessment of
psychosocial support measures for refugees in the context of the crises in Syria and Iraq. It is
aimed at actors from the MHPSS sector working with refugees in the Middle East and at ministries
and academic/scientific institutions in the context of the Syria and Iraq crises.
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Die qualitätive Studie beleuchtet die Umsetzung der Kinderrechte in Flüchtlingsunterkünften aus der Perspektive von Kindern und ihren Eltern. Hierfür wurden in sechs Flüchtlingsunterkünften in drei Bundesländern 70 Interviews mit Kindern und Eltern, aber auch Einrichtungsleitungen und anderen... Akteuren geführt.
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A study conducted by the World Health Organisation Regional Office for Africa. The COVID-19 pandemic has had a significant impact on older persons both globally and in the African region. Although overall the region’s population is younger relative to many other world regions, the WHO AFRO region ...has a population just over 62 million older people and is ageing rapidly, with the number of older people expected to triple in the next three decades (Aboderin et al., 2020).
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Access to controlled medicines. 3rd edition
Empfehlungen für Weiterbildungscurricula für ausgewählte Mitarbeitergruppen
Empfehlungen aus dem Projekt KINDER SCHÜTZEN–STRUKTUREN STÄRKEN! Kinderschutzstandards in Unterkünften für geflüchtete Menschen
La collaboration avec les autorités nationales de gestion des catastrophes
Known avoidable environmental risks to health cause at least 12.6 million deaths every year, and account for about one quarter of the global burden of disease (2016 data) (1). Air pollution alone causes about 7 million
deaths a year, placing it among the top global risks to health (2). Global envir...onmental challenges are on the rise, including climate change, rapid urbanization and increased resistance to drugs.
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