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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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Communicable disease surveillance and response systems

World Health Organization (2006)

Guide to monitoring and evaluating

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The Pediatric Clinical Manual

Elaine Abrams, Wafaa El-Sadr, and Miriam Rabkin The International Center for AIDS Programm (2004)

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Caring for Newborns and Children in the Community. Facilitator Notes

World Health Organization; UNICEF (2011) C_WHO

Treat diarrhoea, confirmed malaria, and fast breathing

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Training Course on the Management of Severe Malnutrition Course Director Guide

WHO WHO (2002)

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Paediatrics for Doctors in Papua New Guinea

Frank Shann and John Vince (2003)

A guide for doctors providing health services for children. 2nd edition

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India: TRAINING OF Link ART Centre (LAC) COUNSELLORS - HANDBOOK FOR TRAINEES

National AIDS Control Organization (NACO), Ministry of Health and Family Welfare, Government of India (2012) C1

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MULTI-SECTORAL NUTRITION IMPLEMENTATION PLAN, RESULTS FRAMEWORK & DASHBOARD OF INDICATORS Namibia

NAFIN (Nambia Alliance for Improved Nutrition) (2013) C2

NAMIBIA (2012/13-2015/16)

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Green Climate Fund Proposal Toolkit 2017: Toolkit to develop a project proposal for the GCF

Fayolle, Virginie; Odianose, Serena Acclimatise, Climate and Development Knowledge Network (CDKN) (2017) C1

The GCF aims to support developing countries in achieving a paradigm shift to low-emission and climate-resilient pathways. This is achieved by funding innovative and transformative lowemission (mitigation) and climate-resilient (adaptation) projects and programmes developed by the public and private... more

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Vision 2030 Development Strategy for Northern Kenya and other Arid Lands

Government of Kenya (2012) C1

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Planetary Health 101 Information and Resources
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Panorma Perspectives (2018) CC

The Panorama Perspectives: Conversations on Planetary Health report series aims to inspire new thinking, conversations, and engagement with planetary health and other integrated concepts. Collaboration and open knowledge sharing across sectors are necessary to solve the complex global health and dev... more

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Guidelines on second-and third-line medicines and type of insulin for the control of blood glucose levels in non-pregnant adults with diabetes mellitus

World Health Organization WHO (2018) C_WHO

The new guidelines provide public health guidance on pharmacological agents for managing hyperglycaemia in type 1 and type 2 diabetes for use in primary health-care in low-resource settings. These guidelines update the recommendations for managing hyperglycaemia in the WHO Package of Essential NCD I... more

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The global doctor

Willott C et al. UCL Institute for Global Health and Development Education Research Centre, Institute of Education (2012) C2

This report explores the reasons why global health is critical to medicine and what this means for medical education. It argues that an understanding of global health is important for all students and practicing doctors, rather than being an ‘add-on’ or ‘option’ for specialization.

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Handbook for Coordinating Gender-based Violence Interventions in Emergencies 2019
recommended

Protection Cluster (2019) C2

This handbook is a quick-reference tool that provides practical, field-level guidance to establish and maintain a GBV sub-cluster in a humanitarian emergency. It provides the foundations for coordination. More in-depth information can be pursued through resources referenced in this handbook. The GBV... more

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Charting the Course of Education and HIV

UNESCO Publishing (United Nations Educational, Scientific and Cultural Organization) (2014) C2

Education on the move

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COVID-19 Vaccine Hesitancy Worldwide: A Concise Systematic Review of Vaccine Acceptance Rates

Sallam, M. (2021) CC

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The Global Status Report on Preventing Violence Against Children 2020

UNICEF WHO (2020) C_WHO

As this report shows, reports of child abuse and of children witnessing violence between their parents and caregivers have increased. Ending violence against children is increasingly within our reach. D

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Monkeypox: Current status in West and Central Africa

World Health Organization (WHO) (2018) C_WHO

Monkeypox is an emerging viral zoonosis with symptoms similar to those observed in smallpox patients, although less severe. Since the global eradication of smallpox in 1980, monkeypox has emerged as the most important orthopoxvirus in humans. The Advisory Committee on Variola Virus Research (ACVVR) ... more