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Current Developments in Malaria Vaccination: A Concise Review on Implementation, Challenges, and Future Directions

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Malaria vaccines: the 60‑year journey of hope and final success—lessons learned and future prospects

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Malaria Vaccine: Questions and Answers on Vaccine Supply, Price and Market Shaping

UNICEF (2024) C_UNICEF
Two malaria vaccines are currently WHO prequalified and recommended1 for use to prevent P. falciparum malaria in young children, the RTS,S/AS01 vaccine, currently manufactured by GlaxoSmithKline (GSK), and the R21/Matrix-M vaccine, manufactured by Serum Institute of India Pvt (SII)
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Routine malaria vaccinations start in Africa

Venkatesan, P. (2024) C1
Lancet Microbe 2024; 5: e519
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RTS,S/AS01 malaria vaccine current evidence, including efficacy, safety, feasibility and impact and update on R21/Matrix-M malaria vaccine

Hamel, M.J. World Health Organization WHO (2023) C_WHO
Presentation OPT-SMC malaria vaccine workshop - Jan 2023
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Malaria vaccines. Summary of the WHO position paper

World Health Organization WHO (2024) C_WHO
WHO position paper on malaria vaccines, Weekly Epidemiological Record 10 May 2024
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Essential Training Packages for Malaria Vaccine Introduction
recommended

World Health Organization WHO (2025) C_WHO
Brief Introduction Malaria Vaccine Training. For countries planning malaria vaccine introduction, WHO has developed training packages of slide sets on key topics for health workers in English and French that can be downloaded and customized to meet specific country needs:
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Introdução breve: Formação da Vacina contra a Malária
recommended

World Health Organization WHO (2025) C_WHO
Programa de Implementação da Vacina contra a Malária: 2019 – 2023.
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Malaria response in urban areas

World Health Organization WHO (2023) C_WHO
Video
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Reactive strategies for reducing malaria transmission in elimination settings

World Health Organisation WHO (2024) C_WHO
This WHO guidance outlines reactive strategies to interrupt malaria transmission in areas nearing elimination or to prevent re-establishment, triggered by confirmed cases.
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Parasitic Infections: Extraintestinal Protozoa - Malaria

Marie, C.; and W.A. Petri (2025) C1
MSD Manual Consumer Version
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Climate impacts on malaria in Africa

Malaria Atlas Project MAP and Boston Consulting Group (2024) CC
This paper is the first quantitative analysis of how the impact of extreme weather events, such as floods and cyclones, affects the malaria burden on the continent, as well as the implications of long-onset climate change. This research involved developing a climate model to predict changes in inten... more
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Climate-proofing a malaria eradication strategy

Nissan, H.; I. Ukawuba, and M. Thomson BMC (2021) CC
Malaria Journal (2021) 20:190
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Malaria and Climate

The Global Fund (2024) CC
Reprogramming examples for GC7. This document supports the introduction of climate change-related interventions into programs to reduce transmission of malaria and protect vulnerable populations.
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Climate change: a hreat to malaria elimination. Is Asia Pacific prepared?

Malaria Consortium; Asia Pacific Leaders Malaria Alliance; TDR; et al. (2021) CC
Thematic brief. This brief highlights the link between climate change and VBDs in Asia Pacific. Using malaria to tell the narrative, it lists key actions that policymakers and the public health community can consider in addressing the impact of a changing climate on health. The brief also includes ... more
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Malaria Lifecycle

Centers for disease control and prevention CDC (2024) C_CDC
Diagram of the malaria lifecycle, including mosquito, human liver, and human blood stages. The diagram also illustrates infective vs diagnostic stages of the parasite's lifecycle. Also included are the temporal views of both p. falciparum and p. vivax.
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Malaria parasite life cycle

PATH (2025) CC
The malaria parasite develops both in humans and in the female Anopheles mosquitoes. The size and genetic complexity of the parasite mean that each infection presents thousands of antigens (proteins) to the human immune system.