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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Malaria control in emergencies: field manual

World Health Organization WHO (2025) C_WHO

Growing emergencies and displacements across the world demand increasingly complex interventions and responses. The World Health Organization (WHO) has developed Malaria control in emergencies: a field manual to provide technical guidance to help partners respond effectively to malaria in emergency ... more

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South Sudan Health Cluster Bulletin 12, December 2018

World Health Organization, Health Cluster (2019) C_WHO

Emergency WASH in Health Facilities in Conflict Affected Locations 756 health workers trained on disease surveillance and outbreak response. Around 142 health workers trained on integrated health (WASH and Nutrition) response. 405 health facilities are equipped with functional incinerators. Qual... more

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In Control: A Practical Handbook for Professionals Working in Health Emergencies Internationally RKI

Robert Koch Institut RKI (2023) CC

The greatest risk to persons engaging in international medical emergency response is poor preparation. The In Control handbook hopes to provide a remedy. At the time of writing, we are living through the Coronavirus (COVID-19) pandemic, a health emergency that disregards physical borders, brin...gs into focus social inequalities and affects people on every continent. This shared challenge requires unprecedented measures and the collaboration of the brightest minds to support global health protection through this crisis and beyond. Healthcare infrastructures have to be strengthened, public health capacities and processes upgraded, medical countermeasures and vaccinations found and psychosocial side-effects treated. Solidarity is the normative order of the day and the human species has to collaborate to face this invisible threat. Hiding and living in fear is not an option in this interconnected world. We have both a responsibility and an opportunity to make substantial contributions to a safer, healthier and more sustainable future for us all. The existence of this handbook is an impressive example of solidarity. Over 50 authors from more than 15 institutes and organisations have come together voluntarily within a very short time to make their expertise available and enable cross-sectoral thinking. Knowledge is bundled, resources are combined, information gaps are filled. The In Control handbook is not a theoretical treatise of possible dangers, but a collection of subject-matter expertise, written by experts and practitioners who have shaped health topics over the past 20 years in the most diverse corners of the world. The Centre for International Health Protection at the Robert Koch Institute (RKI) is collaborating with its partners and investing heavily in the build-up of operational know-how and capacity to support health crisis response abroad. This is done by preparing and enabling professionals to deploy safely across the world to assist those in need. In Control addresses the multi-faceted challenges of an international deployment. Readers will find not only technical medical information, but also insights into, for example, the fragility of our environment, the cultural differences that influence risk communication or the dilemmas arising from social distancing. Legal principles are highlighted, along with ethical guidance to ensure that our actions and decisions correspond to the highest moral standards. more

Oxfam Water Distribution Manual

Oxfam (2006) CC

Oxfam Water Supply Scheme for Emergencies. This manual is part of a series of guides devised by the Oxfam Public Health Engineering Team to help provide a reliable water supply for populations affected by conflict or natural disaster. Wherever possible, water supplies in emergency conditions should ... more

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Water safety plan: a field guide to improving drinking-water safety in small communities

World Health Organization (WHO) (2014) C_WHO

This field guide is a practical tool for improving and maintaining drinking-water safety. It is designed to be used by YOU as a rural community member who shares responsibility for operation and management of the drinking-water supply in your community. It can also be used by YOU as a staff member o... more

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WHO Country Office in Ukraine annual report 2023

World Health Organisation (WHO) (2024) C_WHO

This report provides an overview of the operations and activities of the WHO Country Office in Ukraine in 2023. Despite the acute health impacts of the war in Ukraine, the Country Office continued its work according to its core mandate. WHO supported the Government of Ukraine in managing the health ... more

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North-east Nigeria: Case study

Edwards, Jon Médecins Sans Frontières (MSF) (2017)

This case study examines the humanitarian response to the conflict-related crisis in the North-East of Nigeria, focusing primarily on the period from 2015 to the end of 2016. The aim is test the central hypotheses of the Emergency Gap project: that the current structure, conceptual underpinning and... more

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Disaster Recovery Guidance Series - Communication during Disaster Recovery

World Bank, GFDRR (2019) C1

This Guide provides practical guidance for governments regarding how to effectively communicate with communities during the recovery phase following an emergency. It explains how to identify communication needs, and presents “best fit” communication methods and strategies to deploy to support Di... more

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EVALUATION OF UNICEF PROGRAMMES TO PROTECT CHILDREN IN EMERGENCIES - Synthesis Report

United Nations Children's Fund (UNICEF) (2013) C3

EVALUATION REPORT | The purpose of the evaluation is to strengthen child protection programming in the context of emergencies by assessing UNICEF’s performance and drawing lessons and recommendations that will influence ongoing and future programmes, in both preparedness and response. Apart from g... more

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Pandemic Influenza Risk Management
recommended

World Health Organization WHO (2017) C1

A WHO guide to inform & harmonize national & international pandemic preparedness and response The main updates from the 2013 interim guidance are: Alignment with other relevant United Nations policies for crisis and emergency management, and Inclusion of the significant development in re... more

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Protocol for Enhanced Isolate-Level Antimicrobial Resistance Surveillance in the Americas. Primary Phase: Bloodstream Infections

Pan American Health Organisation PAHO (2021) C_WHO

Antimicrobial resistance (AMR) surveillance plays an important role in the early detection of resistant strains of public health importance and prompt response to outbreaks in hospitals and the community. Surveillance findings are needed to inform medical practice, antibiotic stewardship, and policy... more

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Hospital Readiness Checklist for COVID-19

World Health Organization (Europe) (2020) C_WHO

Interim Version 24, February 2020 This checklist has been prepared with the aim of supporting hospital managers and emergency planners in achieving the above by defining and initiating actions needed to ensure a rapid response to the COVID-19 outbreak. The checklist is structured on eleven key co... more

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Responding to COVID-19: Guidance for humanitarian agencies

ALNAP; CERAH; LSHTM (2020) C2

How should humanitarian organisations prepare and respond to COVID-19 in humanitarian settings in low- and middle-income countries? This Rapid Learning Review outlines 14 actions, insights and ideas for humanitarian actors to consider in their COVID-19 responses. It summarises and synthesises the... more

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Safe Distributions: Guidelines for Reducing Protection Risks in in-kind Distributions

UNHCR (2020) CC

Distributing immediate, lifesaving assistance is one of the most urgent actions in an emergency response and can significantly improve the safety and wellbeing of individuals. Non-Food Items (NFI), Food Security, WASH and Shelter in-kind assistance actors can help reduce and mitigate pr... more

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A practical guide for developing Child Friendly Spaces

UNICEF (2016) CC

This guide is designed to assist UNICEF staff and partners, in establishing and operating Child Friendly Spaces (CFS) in an emergency. It attempts to provide readers with the main principles of a CFS and the processes on how to establish one. The overall aim is to improve the standards and capac... more

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Workplace Pandemic Preparedness. Training Manual
recommended

Ministry of Health Ghana; NADMO Ghana GiZ Deutsche Gesellschaft für Internationale Zusammenarbeit (2013) C1

A training manual for identifying, assessing, preventing and controlling the risks of pandemics in the workplace. This training manual has been developed for both medical and non-medical personnel who may be called upon to lead emergency response, (eg epidemic outbreak, etc), ensure effective conta... more

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Prise en charge clinique, prévention et maîtrise de l'orthopoxvirose simienne (‎variole du singe)‎ : orientations provisoires pour une intervention rapide, 10 juin 2022
recommended

World Health Organization WHO (2022) C_WHO

Interim rapid response guidance, 10 June 2022. It includes considerations for certain populations such as patients with mild disease with considerations for community care, patients with moderate to severe disease, sexually active persons, pregnant or breastfeeding women, children and young persons... more

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Responding to a polio outbreak. Guidelines
recommended

Polio Global Eradication Intiative (2011)

The occurrence of a case of wild polio in a previously polio free area as presently in Syria, whether through importation, laboratory accident, or mutation of vaccine virus (VDPV), should be considered a public health emergency, that requires a rapid and high quality response as utmost priority

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Health Sector Disaster Recovery Framework Guide

UN Development Programme; World Health Organization WHO (2023) CC

The Disaster Recovery Framework (DRF) Guide for the Health Sector provides guidance on how to implement a comprehensive, integrated, and structured approach to disaster recovery. Its overarching goal is to minimize the impact of the disaster on communities and help countries to recover quickly and e... more

Pandemic Influenza Risk Management recommended

Workplace Pandemic Preparedness. Training Manual recommended

Prise en charge clinique, prévention et maîtrise de l'orthopoxvirose simienne (‎variole du singe)‎ : orientations provisoires pour une intervention rapide, 10 juin 2022 recommended

Responding to a polio outbreak. Guidelines recommended

Pandemic Influenza Risk Management
recommended

Workplace Pandemic Preparedness. Training Manual
recommended

Prise en charge clinique, prévention et maîtrise de l'orthopoxvirose simienne (‎variole du singe)‎ : orientations provisoires pour une intervention rapide, 10 juin 2022
recommended

Responding to a polio outbreak. Guidelines
recommended