Prevention of mother-to-child HIV transmission (PMTCT) has been a success in many respects but there is still much to do to eliminate mother-to child transmission (MTCT), particularly in low antiretroviral therapy (ART) coverage areas and in the postnatal phase. The success of PMTCT is highly dependent on the availability and accessibility of patient-centred care, which enables women and their families to take informed decisions about their health and the health of their infant. For this reason, it is recommended to have a patient-centred approach when implementing PMTCT. PMTCT success is also linked to the partners’ involvement, as well as to community acceptance of HIV.