Clinical management standard operating procedures.
Ebola virus disease (EVD) is a life-threatening multisystem illness associated with fever and gastrointestinal (GI) symptoms that frequently leads to hypovolaemia, metabolic acidosis, hypoglycaemia, and multi-organ failure. The prolonged 2013–2016 EVD outbreak in West Africa allowed for an evolution of care such that by outbreak end many patients received individualized and optimized supportive care (oSoC), including volume resuscitation, symptom control, laboratory and bedside monitoring of glucose, electrolyte levels and organ dysfunction, as well as rapid detection and treatment of co-infections, potentially contributing to the downward trend in the case fatality rate (CFR).
This guidance should serve as a foundation for oSoC that should be followed to ensure both the best possible chance for survival and allow for reliable comparison of investigational therapeutic interventions as part of a randomized controlled trial. This guideline provides recommendations for the management of adults and children.
The purpose of this pocketbook is to provide clear guidance on current best management practices for VHF across health-care facilities
This document provides a summary of infection control recommendations when providing direct and non-direct care to patients with suspected or confirmed Filovirus haemorrhagic fever (HF), including Ebola or Marburg haemorrhagic fevers. These recommendations are interim and will be updated when additional information becomes available.
The latest clinical information about the epidemiology, diagnosis and treatment of viral haemorrhagic fevers, published in the well-known medical textbook ‘Manson’s Tropical Diseases’, has been made freely available by the publisher.
The chapter is aimed at doctors around the world treating patients with all types of viral haemorrhagic fevers. These include Ebola, Margburg fever, Lassa fever, Lujo haemorrhagic fever, South American haemorrhagic fevers and Bunyavirus diseases including Rift Valley fever and Crimean-Congo haemorrhagic fever.
Reproduced from: Farrar J et al. Manson’s Tropical Diseases. 23rd edn. Elsevier; 2014. Chapter 16: Blumberg L et al. Viral Haemorrhagic Fevers. pp. 171-94. © 2014, with permission from Elsevier. ISBN 978-0-7020-5102-9
Important Guideline for Ebola prevention and control
It is designed for the following uses:
- for prevention through preparedness--to help African health facilities make advance preparations for responding with appropriate precautions when a VHF (including Ebola) case is suspected.
- for planning and conducting in-service training to strengthen standard precautions and VHF isolation precautions.
- as a rapid reference when a VHF (i.e. Ebola) case appears at a health facility where no previous VHF preparations have been made.