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EPI 1: Antiepileptic medications for management of acute convulsive seizures when no intravenous access is available

World Health Organization WHO, (2015)


[Updated 2015] Scoping Question: In adults with acute convulsive seizures in first-level care or in the community (when no IV access is available), which antiepileptic medications produce benefits and/or harm when compared to comparator?
https://www.who.int/mental_health/mhgap/evidence/r...


EPI 4: Antiepileptic medications for adults and children with HIV

World Health Organization WHO, (2015)


Scoping Question: For adults and children living with HIV, which antiepileptic medications (such as phenobarbital, phenytoin, carbamazepine or valproic acid) produce benefits and/or harms when compared to a placebo or controls?
https://www.who.int/mental_health/mhgap/evidence/r...


EPI 2: First-line anti-epileptic medication for management of acute convulsive seizures, when intravenous access is available [2015]

Eds.: mhGAP; WHO, (2015)


SCOPING QUESTION: In adults with acute convulsive seizures, where intravenous access is available, which first-line anti- epileptic medication should be used to abort seizures when compared to comparator?
https://www.who.int/mental_health/mhgap/evidence/r...


EPI 5: Anti-epileptic medicines for medication resistant convulsive epilepsy. [New 2015]

Eds.: mhGAP; WHO, (2015)


SCOPING QUESTION: For adults and children with medication-resistant convulsive epilepsy, which anti-epileptic medications produce benefits and/or harm in the specified outcomes when compared to a placebo or a comparator?
https://www.who.int/mental_health/mhgap/evidence/r...


EPI 3: Anti-epileptic medications for management of established status epilepticus [Updated 2015]

Eds.: mhGAP; WHO, (2015)


SCOPING QUESTION: In adults with established status epilepticus (i.e., seizures persisting after the first-line treatment with benzodiazepines [or benzodiazepines-resistant status epilepticus]), which anti-epileptic medications are associated with cessation of seizures and reduced adverse effects)?
https://www.who.int/mental_health/mhgap/evidence/r...


Management of epilepsy in women of child bearing age

Eds.: World Health Organization, (2012)


Q11: 11a). In women with epilepsy, should antiepileptic therapy be prescribed as monotherapy or polytherapy to decrease the risk of fetal malformations? 11b). Does the use of folic acid preconceptually decrease the risk of foetal malformations in women with epilepsy? 11c). Do phenytoin, phenobarbital, valproic acid or carbamazepine enter breast milk in quantities which are clinically significant to the baby?
https://www.who.int/mental_health/mhgap/evidence/r...


Management of febrile seizures

World Health Organization WHO, (2012)


Q3: Can febrile seizures (simple or complex) be managed at first or second level care by non-specialist health care providers in low and middle income country settings? What is the role of diagnostic tests in the management of febrile seizures by non-specialists in low and middle income settings? For prophylaxis to prevent recurrence of simple or complex febrile seizures, which of the pharmacological interventions when compared with placebo/comparator produce benefit/harm in specified outcomes? - continuous anticonvulsant therapy - intermittent anticonvulsant therapy - intermittent antipyretic treatment
https://www.who.int/mental_health/mhgap/evidence/r...


Role of EEG in management of convulsive epilepsy

World Health Organization WHO, (2012)


Q5: What is the added advantage of doing an electroencephalography (EEG) in people with convulsive epilepsy in non- specialist settings in low and middle income countries?
https://www.who.int/mental_health/mhgap/evidence/r...


Standard antiepileptic drugs (phenobarbital, phenytoin, carbamazepine, valproic acid) for management of convulsive epilepsy in adults and children

Eds.: World Health Organization, (2012)


Q 7: For adults and children with convulsive epilepsy, which standard antiepileptic drugs (phenobarbital, phenytoin, carbamazepine, valproic acid) when compared to placebo/a comparator produce benefits/harm in the specified outcomes?
https://www.who.int/mental_health/mhgap/evidence/r...


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