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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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Interim Guidance on Public Health and Social Measures for COVID-19 Preparedness and Response Operations in Low Capacity and Humanitarian Settings

Inter-Agency Standing Committee IASC (2020) C1

This Interim Guidance outlines how key public health and social measures needed to reduce the risk of COVID-19 spread and the impact of the disease can be adapted for use in low capacity and humanitarian settings. The recommendations outlined here need to be adjusted to the scale of transmission, co... more

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Antenatal Guidelines for Primary Health Care in Crisis Conditions

Cristina Otero Garcia ICRC (2005)

These guidelines are designed for ICRC and other health professionals – nurses, midwifes, doctors – who either lack experience in antenatal care or are not used to working in countries where medical infrastructure is underdeveloped or non-existent

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WHO consolidated guideline on self-care interventions for health: sexual and reproductive health and rights

World Health Organization WHO (2019) C_WHO

Self-care interventions are among the most promising and exciting new approaches to improve health and well-being, both from a health systems perspective and for people who use these interventions. The World Health Organization (WHO) uses the following working definition of self-care: Self-care is t... more

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Broader health impacts of vertical responses to COVID-19 in low- and middle-income countries

Tabitha Hrynick, T.; S. Ripoll and S. Carter Social Science in Humanitarian Action (2021) C1

This paper reviews the effects of vertical responses to COVID-19 on health systems, services, and people’s access to and use of them in LMICs, where historic and ongoing under-investments heighten vulnerability to a multiplicity of health threats. We use the term ‘vertical response’ to describ... more

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Survey Tool and Guidance: Rapid, simple, flexible behavioural insights on COVID-19

World Health Organization WHO (2020) C_WHO

This document provides guidance to Member States in the WHO European Region that wish to conduct behavioural insights studies related to COVID-19. Studies can be used to monitor public knowledge, risk perceptions, behaviours and trust with the overall aim to inform national COVID-19 outbreak respons... more

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Where There Are No Pharmacists

Sarah Andersson; Beverley Snell Third World Network; Health Action International Asia Pacific (2019) C2

2nd edition. A Guide to Managing Medicines for All Health Workers. Available for purchase via following link https://www.twn.my/title2/books/HAI.htm Where there are no trained pharmacists serving communities, other categories of health workers are called upon to order, buy, store, dispense and ad... more

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NIGERIA STATE DATA PROFILES: An Accountability Tool for Maternal, Newborn and Child Health in Nigeria

Save the Children International (2014) C2

Nigeria is Africa’s most populous nation and accounts for nearly one quarter of the continent’s maternal, newborn and child deaths. In the spirit of the global Countdown to 2015 for Maternal, Newborn and Child Health and the Nigerian Saving One Million Lives Initiative, these state data profiles... more

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Sierra Leone Cholera ERU Operation Review

International Federation of Red Cross and Red Crescent Society (IFRC) (2013)

This review of the IFRC support to the Sierra Leone Red Cross Society response to the 2012 cholera outbreak provides ideas and concepts to promote a more coherent and evidence based rationale on how to make more effective use of IFRC global assets to stop, control, mitigate and respond to cholera ep... more

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Chronic Obstructive Pulmonary Disease (COPD) - Patient Education; Information

Lareau S.C., Fahy B. et al American Thoracic Society (2019) CC2

The document by the American Thoracic Society provides an overview of Chronic Obstructive Pulmonary Disease (COPD), explaining its causes, such as smoking and environmental factors, symptoms like breathlessness and chronic cough, and diagnostic methods including spirometry. It discusses treatment st... more

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Guidelines for Care of Critically Ill Adult Patients with COVID-19 in the Americas. Summary, version 3

Pan American Health Organisation PAHO (2021) C_WHO

This publication provides recommendations for the management of critically ill adult patients with COVID-19 being treated in intensive care units (ICUs) in the Americas. These clinical practice guidelines provide evidence-informed recommendations for identifying markers and mortality risk factors in... more

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Guidelines for Maternity Care in South Africa - fourth edition 2016

Maternal Health Committee of the National Department of Health (NDoH) South Africa NDoH South Africa (2016) CC

These guidelines have been prepared by the Sub directorate: Maternal Health for the guidance of health workers (doctors and midwives) providing obstetric, surgical and anaesthetic services for pregnant women in district clinics, health centres and district hospitals. These guidelines are intended fo... more

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WHO good manufacturing practices for pharmaceutical products: main principles

World Health Organization WHO (2014) C_WHO

Licensed pharmaceutical products (marketing authorization) should be manufactured only by licensed manufacturers (holders of a manufacturing authorization) whose activities are regularly inspected by competent national authorities. This guide to GMP shall be used as a standard to justify GMP status,... more

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Connecting Global Priorities: Biodiversity and Human Health

World Health Organization WHO (2015) C_WHO

Healthy communities rely on well-functioning ecosystems. They provide clean air, fresh water, medicines and food security. They also limit disease and stabilize the climate. But biodiversity loss is happening at unprecedented rates, impacting human health worldwide, according to a new state of knowl... more

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Implementation manual to prevent and control the spread of carbapenem-resistant organisms at the national and health care facility level
recommended

World Health Organization WHO (2020) C_WHO

This manual presents a compelling case for action on carbapenem-resistant organisms (CROs) and describes the linkages between the prevention and control of CROs and the Global Action Plan on Antimicrobial Resistance (AMR). It describes how the eight recommendations contained within the World Health ... more

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Delivering quality health services: A global imperative for universal health coverage

Kieny, Marie-Paule; Evans, Timothy Grant; Scarpetta, Stefano; Kelley, Edward T.; Klazinga, Niek; Forde, Ian; Veillard, Jeremy Henri Maurice; Leatherman, Sheila; Syed, Shamsuzzoha; Kim, Sun Mean; Nejad, Sepideh Bagheri; Donaldson, Liam World Health Organization (WHO), Organisation for Economic Co-operation and Development (OECD), and The World Bank (2018) C_WHO

Poor quality health services are holding back progress on improving health in countries at all income levels.
Today, inaccurate diagnosis, medication errors, inappropriate or unnecessary treatment, inadequate or unsafe clinical facilities or practices, or providers who lack adequate training an... more

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National Comprehensive Covid19 Management Handbook First Edition 2020

Ministry of Health, Federal Democratic Republic of Ethiopia Ministry of Health, Federal Democratic Republic of Ethiopia (2020) C1

Cognizant of the need for standardization of the response for COVID-19, the Federal Ministry of Health prepared this national guideline in an effort to contain the epidemic before it overwhelms the health care facilities. This national guideline is expected to guide policy makers and h... more

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Integrated Surveillance of Antimicrobial Resistance in Foodborne Bacteria:Application of a One Health Approach

World Health Organization WHO (2017) C_WHO

The purpose of this guidance is to assist WHO Member States, and other stakeholders, in the establishment and development of programmes of integrated surveillance of antimicrobial resistance in foodborne bacteria (i.e., bacteria commonly transmitted by food). In this guidance, “integrated surveill... more

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Dengue vaccine: WHO position paper May 2024

World Health Organization WHO (2024) C_WHO

Weekly epidemiological recordRelevé épidémiologique hebdomadaire 3 MAY 2024, 99th YEAR / 3 MAI 2024, 99e ANNÉE No 18, 2024, 99, 203–224 The WHO position papers are concerned primarily with the use of vaccines in large-scale vaccination programmes. The position papers are intended for use by... more

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WHO preferred product characteristics for gonococcal vaccines

World Health Organization WHO (2021) C_WHO

Development of one or more vaccines for Neisseria gonorrhoeae is an important objective for sexual and reproductive health worldwide, and for the fight against antimicrobial resistance. WHO preferred product characteristics (PPCs) provide strategic guidance as to WHO’s preferences for new vacci... more

Implementation manual to prevent and control the spread of carbapenem-resistant organisms at the national and health care facility level recommended

Implementation manual to prevent and control the spread of carbapenem-resistant organisms at the national and health care facility level
recommended