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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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WHO manual for HIV drug resistance testing using dried blood spot specimens

World Health Organization WHO (2020) C_WHO

HIV-1 drug resistance (HIVDR) genotyping is an essential component of the WHO global HIVDR surveillance strategy. Plasma “gold standard” specimen type for HIVDR genotyping, but its use may not be feasible in rural, remote areas in low- and middle-income countries, since preparing and storing it ... more

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Problem Management Plus (PM+)
recommended

World Health Organization WHO (2016) C_WHO

Individual psychological help for adults impaired by distress in communities exposed to adversity. The manual describes a scalable psychological intervention called Problem Management Plus (PM+) for adults impaired by distress in communities who are exposed to adversity. Aspects of Cognitive Behavi... more

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Guidelines for the Development of Pharmaceutical Services in Primary Health Care

Pan American Health Organization (PAHO) (2011) C_WHO

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National HIV/Syphilis sero-prevalence sentinel survey among pregnant women attending antenatal clinics in Nigeria

Federal Ministry of Health, Dept. of Public Health, National HIVSTI (2005) C1

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HIV/AIDS treatment and care in Belarus

J. D. Lundgren; D. Raben; I. Eramova; V. Ilyenkova World Health Organization (Europe); Centre for Heath & Infectious Disease Research (2014) C_WHO

Evaluation report January 2014

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Community Health Volunteers' Decision Support System Project

P. Bakibinga, Kamande E. , Kisia L., et al. African Population and Health Research Centre APHRC (2018) C1

This report presents the key findings of the end-of-project assessment of households and community health volunteers, conducted in 2017 in the Kamukunji and Embakasi sub-counties of Nairobi, Kenya, for a Community Health Volunteers’ Decision Support System (CHV DSS) intervention project. The re... more

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HOW TO CONDUCT MATERNAL DEATH REVIEWS (MDR)

De Brouwere V., Zinnen V., Delvaux T. (2013)

Guidelines and tools for Health Professionals

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Health interventions for older people in emergencies

Fritsch, P. Help Age International; ECHO (2013) CC

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The Logistics Handbook - A Practical Guide for the Supply Chain Management of Health Commodities

USAID USAID (2011)

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Health Care Waste Management Manual, Fourth Edition

Department of Health Philippines (2020) CC

This document shall serve as the most comprehensive set of guidelines on the safe management of waste generated from heath care activities in the country. It incorporates the requirements of all Philippine laws and regulations governing HCWM and is designed for the use of individuals, public and pri... more

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Emergency triage assessment and treatment (‎‎‎ETAT). Manual for Participants

World Health Organization (2005) C_WHO

The Manual for Participants is primarily meant for the participants of a 3 and a half day training course in Emergency Triage, Assessment and Treatment.

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Journey of ART Programme in India. Story of a decade

National AIDSControl (NACO), Government of India; Ministry of Health and Family Welfare, et al. (2015) C1

Celebrating ten years of success 2004-2014

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Primary ear and hearing care training resource (ADVANCED LEVEL)

World Health Organization (WHO) (2006) C_WHO

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Survey of the Quality of Selected Antimalarial Medicines Circulating in Six Countries of Sub-Saharan Africa
recommended

World Health Organization WHO (2011) C_WHO

The survey aimed at evaluating the quality of selected antimalarials in six countries of sub-Saharan Africa (Cameroon, Ethiopia, Ghana, Kenya, Nigeria and the United Republic of Tanzania). These countries have been supported by WHO to strengthen their regulatory controls o... more

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Antimicrobial Resistance Surveillance Guidance for the African Region

Africa Center for Disease Control and Prevention (2024) CC

Antimicrobials are medicines, including antibiotics, antivirals, antifungals, and antiparasitics, that are used to prevent and treat infections in humans, animals, and plants. Antimicrobial Resistance (AMR) arises when bacteria, viruses, fungi, and parasites no longer respond to these medicines, ren... more

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Abortion care guideline

World Health Organization WHO (2022) C_WHO

The objective of this guideline is to present the complete set of all WHO recommendations and best practice statements relating to abortion. While legal, regulatory, policy and service-delivery contexts may vary from country to country, the recommendations and best practices described in this docume... more