Chapter 1 of the WHO manual for male circumcision as an HIV prevention strategy provides an overview of how medical male circumcision (VMMC) can reduce the risk of female-to-male HIV transmission. It explains that VMMC is an effective and safe risk-reduction method that, according to three randomized controlled trials, reduces HIV acquisition by approximately 60%. The chapter highlights that VMMC should be offered as part of a combination prevention approach, alongside other strategies like safer sex education and condom use, to address concerns about potential behavioral changes.